Evidence map›Paper›PMID 30513862›Full record

ArticleMarine drugs2018

Synthesis and Antiproliferative Activity of Marine Bromotyrosine Purpurealidin I and Its Derivatives.

Chinmay Bhat, Polina Ilina, Irene Tilli, Manuela Voráčová, Tanja Bruun, Victoria Barba, Nives Hribernik, Katja-Emilia Lillsunde, Eero Mäki-Lohiluoma, Tobias Rüffer and 4 more

Abstract read
In one paragraph

Article in Marine drugs, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Structure-Function Studies of Sponge-Derived Compounds on the Cardiac CaInternational journal of molecular sciences · 2023
    Article
  3. Naturally Occurring Organohalogen Compounds-A Comprehensive Review.Progress in the chemistry of organic natural products · 2023
    Review
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chinmay BhatDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, Viikinkaari 5 E (P.O. Box 56), University of Helsinki, FI-00014 Helsinki, Finland. chinmay.bht@gmail.com.
Polina IlinaDrug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, Viikinkaari 5 E (P.O. Box 56), University of Helsinki, FI-00014 Helsinki, Finland. polina.ilina@helsinki.fi.
Irene TilliDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, Viikinkaari 5 E (P.O. Box 56), University of Helsinki, FI-00014 Helsinki, Finland. irene.tilli@helsinki.fi.
Manuela VoráčováDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, Viikinkaari 5 E (P.O. Box 56), University of Helsinki, FI-00014 Helsinki, Finland. manuelavorac@gmail.com.
Tanja BruunDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, Viikinkaari 5 E (P.O. Box 56), University of Helsinki, FI-00014 Helsinki, Finland. tanja.bruun@helsinki.fi.
Victoria BarbaDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, Viikinkaari 5 E (P.O. Box 56), University of Helsinki, FI-00014 Helsinki, Finland. victoria.barba@ens-lyon.fr.
Nives HribernikDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, Viikinkaari 5 E (P.O. Box 56), University of Helsinki, FI-00014 Helsinki, Finland. nives.hribernik@gmail.com.
Katja-Emilia LillsundeDrug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, Viikinkaari 5 E (P.O. Box 56), University of Helsinki, FI-00014 Helsinki, Finland. katja-emilia.lillsunde@helsinki.fi.
Eero Mäki-LohiluomaDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, Viikinkaari 5 E (P.O. Box 56), University of Helsinki, FI-00014 Helsinki, Finland. Eero.Maki-Lohiluoma@orion.fi.
Tobias RüfferInstitute of Chemistry, Technische Universität Chemnitz, 09107 Chemnitz, Germany. tobias.rueffer@chemie.tu-chemnitz.de.
Heinrich LangInstitute of Chemistry, Technische Universität Chemnitz, 09107 Chemnitz, Germany. heinrich.lang@chemie.tu-chemnitz.de.
Jari Yli-KauhaluomaDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, Viikinkaari 5 E (P.O. Box 56), University of Helsinki, FI-00014 Helsinki, Finland. jari.yli-kauhaluoma@helsinki.fi.
Paula KiuruDrug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, Viikinkaari 5 E (P.O. Box 56), University of Helsinki, FI-00014 Helsinki, Finland. paula.kiuru@helsinki.fi.
Päivi TammelaDrug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, Viikinkaari 5 E (P.O. Box 56), University of Helsinki, FI-00014 Helsinki, Finland. paivi.tammela@helsinki.fi.ORCID 0000-0003-4697-8066

Funding

Academy of Finland 285103Academy of Finland 315937Seventh Framework Programme FP7-KBBE-2009-3-245137
6 · The paper itself

Abstract

The first total synthesis of the marine bromotyrosine purpurealidin I (

Indexed as

Drug DevelopmentAnimalsAntineoplastic AgentsAquatic OrganismsCell Line, TumorDrug Screening Assays, AntitumorFibroblastsHumansMolecular StructurePoriferaPyridinesStructure-Activity RelationshipTyrosineAntineoplastic Agentsbromotyrosinepurpurealidin IPyridinesTyrosinebromotyrosinescytotoxicityPseudoceratina purpureaPurpurealidin Iselectivity to cancer cellssynthesis

Identifiers

PMID30513862
PMCPMC6316490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.