Evidence map›Paper›PMID 30513821›Full record

ArticleToxins2018

Human Recombinant Fab Fragment Neutralizes Shiga Toxin Type 2 Cytotoxic Effects

Daniela Luz, Maria Marta Amaral, Flavia Sacerdoti, Alan Mauro Bernal, Wagner Quintilio, Ana Maria Moro, Marina Sandra Palermo, Cristina Ibarra, Roxane Maria Fontes Piazza

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Therapeutic Antibodies Against Shiga Toxins: Trends and Perspectives.Frontiers in cellular and infection microbiology · 2022
    Review
  3. Article
  4. Article
  5. Review
  6. Treatment Strategies for Infections With Shiga Toxin-ProducingFrontiers in cellular and infection microbiology · 2020
    Review
  7. Anti-biofilm and Antibacterial Activity ofIndian journal of microbiology · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Daniela LuzLaboratório de Bacteriologia, Instituto Butantan, São Paulo 05503900, Brasil. daniedaluz@yahoo.com.br.
Maria Marta AmaralLaboratorio de Fisiopatogenia, Departamento de Fisiología, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121, Argentina. mmamaral74@gmail.com.
Flavia SacerdotiLaboratorio de Fisiopatogenia, Departamento de Fisiología, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121, Argentina. flasacerdoti@gmail.com.
Alan Mauro BernalLaboratorio de Patogénesis e Inmunología de Procesos Infecciosos, Instituto de Medicina Experimental, (IMEX)-CONICET-Academia Nacional de Medicina, Buenos Aires C1425, Argentina. alanmbernal@gmail.com.
Wagner QuintilioLaboratório de Biofármacos em Células Animais, Instituto Butantan, São Paulo, SP 05503-900, Brazil. wagner.quintilio@butantan.gov.br.ORCID 0000-0002-3382-8184
Ana Maria MoroLaboratório de Biofármacos em Células Animais, Instituto Butantan, São Paulo, SP 05503-900, Brazil. ana.moro@butantan.gov.br.ORCID 0000-0002-0650-7764
Marina Sandra PalermoLaboratorio de Patogénesis e Inmunología de Procesos Infecciosos, Instituto de Medicina Experimental, (IMEX)-CONICET-Academia Nacional de Medicina, Buenos Aires C1425, Argentina. marinasandrapalermo@gmail.com.
Cristina IbarraLaboratorio de Fisiopatogenia, Departamento de Fisiología, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO Houssay-CONICET), Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121, Argentina. cristinaadrianaibarra@gmail.com.ORCID 0000-0001-8182-501X
Roxane Maria Fontes PiazzaLaboratório de Bacteriologia, Instituto Butantan, São Paulo 05503900, Brasil. roxane@butantan.gov.br.ORCID 0000-0003-0068-8506
Instituto Butantan · BRConsejo Nacional de Investigaciones Científicas y Técnicas · ARAcademia Nacional de Medicina · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shiga toxin (Stx) producing

Indexed as

AnimalsAntibodies, MonoclonalAntibodies, NeutralizingCells, CulturedCell SurvivalEndothelial CellsHumansImmunoglobulin Fab FragmentsKidney GlomerulusMice, Inbred BALB CRecombinant ProteinsShiga Toxin 2Antibodies, MonoclonalAntibodies, NeutralizingImmunoglobulin Fab FragmentsRecombinant ProteinsShiga Toxin 2Fabneutralizationprotectionrecombinant antibody fragmentShiga toxin

Identifiers

PMID30513821
PMCPMC6315604
OpenAlexW2902133997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.