ArticleJournal of clinical medicine2018
Clinical Course, Serologic Response, and Long-Term Outcome in Elderly Patients with Early Lyme Borreliosis.
Article in Journal of clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 35 citations in OpenAlex.
- Trial
- Lyme borreliosis.Nature reviews. Disease primers · 2026Review
- Clinical Manifestations of Lyme Borreliosis in Europe: Burden of Lyme Disease Study (BOLD), 2021-2022.Pathogens (Basel, Switzerland) · 2026Article
- Evaluation of immunoreactive epitopes in the sera and cerebrospinal fluid of patients with post-treatment Lyme disease syndrome.Scientific reports · 2026Article
- Climate crisis risks to elderly health: strategies for effective promotion and response.Health promotion international · 2024Review
- Pediatric Lyme disease: systematic assessment of post-treatment symptoms and quality of life.Pediatric research · 2024Article
- Determinants of persistent symptoms after treatment for Lyme borreliosis: a prospective observational cohort study.EBioMedicine · 2023Observational
- Association of Persistent Symptoms after Lyme Neuroborreliosis and Increased Levels of Interferon-α in Blood.Emerging infectious diseases · 2023Review
- Non-specific symptoms and post-treatment Lyme disease syndrome in patients with Lyme borreliosis: a prospective cohort study in Belgium (2016-2020).BMC infectious diseases · 2022Article
- Persistent Symptoms After Treatment of Lyme Disease.Infectious disease clinics of North America · 2022Review
- Borrelial lymphocytoma.Wiener klinische Wochenschrift · 2022Review
- The presenting characteristics of erythema migrans vary by age, sex, duration, and body location.Infection · 2021Article
- Characteristics of spirochetemic patients with a solitary erythema migrans skin lesion in Europe.PloS one · 2021Article
- Experiences with tick exposure, Lyme disease, and use of personal prevention methods for tick bites among members of the U.S. population, 2013-2015.Ticks and tick-borne diseases · 2021Article
- Posttreatment Symptoms in Lyme Borreliosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Dynamics ofMicroorganisms · 2020Article
- Course and Outcome of Erythema Migrans in Pregnant Women.Journal of clinical medicine · 2020Article
- Early Lyme Borreliosis in Patients Treated with Tumour Necrosis Factor-Alfa Inhibitors.Journal of clinical medicine · 2019Article
- Antibiotic Use and Long-Term Outcome in Patients with Tick-Borne Encephalitis and Co-Infection withJournal of clinical medicine · 2019Article
- Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Infected elderly people often present with signs and symptoms that differ from those in younger adults, but data on the association between patient age and presentation of early Lyme borreliosis (LB) are limited. In this study, the association between patient age (18⁻44 years, young vs. 45⁻64 years, middle-aged vs. ≥ 65 years, elderly) and disease course, microbiologic characteristics, and the long-term outcome of treatment was investigated prospectively in 1220 adult patients with early LB manifesting as erythema migrans (EM) at a single-center university hospital. Patients were assessed at enrolment and followed-up for 12 months. Age was associated with comorbidities, previous LB, presenting with multiple EM, and seropositivity to borreliae at enrolment. The time to resolution of EM after starting antibiotic treatment was longer in older patients. At 12 months, 59/989 (6.0%) patients showed incomplete response. The odds for incomplete response decreased with time from enrolment (odds ratio (OR) of 0.49, 0.50, and 0.48 for 2-month vs. 14-days, 6-month vs. 2-month, and 12-month vs. 6-month follow-up visits, respectively), but were higher with advancing age (OR 1.57 for middle-aged vs. young, and 1.95 for elderly vs. young), in women (OR 1.41, 95% confidence interval (CI) 1.01⁻1.96), in patients who reported LB-associated constitutional symptoms at enrolment (OR 7.69, 95% CI 5.39⁻10.97), and in those who presented with disseminated disease (OR 1.65, 95% CI 1.09⁻2.51). The long-term outcome of EM was excellent in patients of all age groups. However, older patients had slower resolution of EM and higher odds for an unfavorable outcome of treatment (OR 1.57, 95% CI 1.05⁻2.34 for middle-aged vs. young; and OR 1.95, 95% CI 1.14⁻3.32 for elderly vs. young), manifested predominantly as post-LB symptoms. The presence of LB-associated constitutional symptoms at enrolment was the strongest predictor of incomplete response.
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