Evidence map›Paper›PMID 30513800›Full record

ArticleJournal of clinical medicine2018

Fatty Acid-Binding Protein 4-An "Inauspicious" Adipokine-In Serum and Urine of Post-Partum Women with Excessive Gestational Weight Gain and Gestational Diabetes Mellitus.

Żaneta Kimber-Trojnar, Jolanta Patro-Małysza, Marcin Trojnar, Katarzyna E Skórzyńska-Dziduszko, Jacek Bartosiewicz, Jan Oleszczuk, Bożena Leszczyńska-Gorzelak

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Incretins as a Potential Treatment Option for Gestational Diabetes Mellitus.International journal of molecular sciences · 2022
    Review
  6. Review
  7. Article
  8. Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus 2.0.International journal of molecular sciences · 2022
    Review
  9. Novel Biomolecules in the Pathogenesis of Gestational Diabetes Mellitus.International journal of molecular sciences · 2021
    Review
  10. Review
  11. The Latest Insights into Adipokines in Diabetes.Journal of clinical medicine · 2019
    Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Żaneta Kimber-TrojnarChair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland. zkimber@poczta.onet.pl.ORCID 0000-0001-7295-0409
Jolanta Patro-MałyszaChair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland. jolapatro@wp.pl.ORCID 0000-0002-4118-7698
Marcin TrojnarChair and Department of Internal Medicine, Medical University of Lublin, 20-081 Lublin, Poland. marcin.trojnar@umlub.pl.ORCID 0000-0001-9318-1995
Katarzyna E Skórzyńska-DziduszkoChair and Department of Human Physiology, Medical University of Lublin, 20-080 Lublin, Poland. katarzyna.skorzynska-dziduszko@umlub.pl.ORCID 0000-0002-8718-1187
Jacek BartosiewiczChair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland. jacek.bartosiewicz@umlub.pl.
Jan OleszczukChair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland. jan.oleszczuk@umlub.pl.
Bożena Leszczyńska-GorzelakChair and Department of Obstetrics and Perinatology, Medical University of Lublin, 20-090 Lublin, Poland. b.leszczynska@umlub.pl.
Medical University of Lublin · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The exact roles of adipokines in the pathogenesis of type 2 diabetes and obesity are still unclear. The aim of the study was to evaluate fatty acid binding protein 4 (FABP4) concentrations in the serum and urine of women with excessive gestational weight gain (EGWG) and gestational diabetes mellitus (GDM) in the early post-partum period, with reference to their laboratory test results, body composition, and hydration status. The study subjects were divided into three groups: 24 healthy controls, 24 mothers with EGWG, and 22 GDM patients. Maternal body composition and hydration status were evaluated by the bioelectrical impedance analysis (BIA) method. Concentrations of FABP4, leptin, and ghrelin were determined via enzyme-linked immunosorbent assay (ELISA). Healthy women were characterized by the lowest serum leptin concentrations and by a negative correlation between the serum and urine FABP4 levels. Serum FABP4 levels were the highest in the GDM group. Serum FABP4 and leptin concentrations correlated positively in the GDM group. The EGWG group had the highest degree of BIA disturbances in the early puerperium and positive correlations between the urine FABP4 and serum leptin and ghrelin concentrations. The physiological and pathological significance of these findings requires further elucidation.

Indexed as

adipokinesbioelectrical impedance analysisbody compositionexcessive gestational weight gainfatty acid binding protein 4gestational diabetes mellitushydration statusleptintype 2 diabetes mellitus

Identifiers

PMID30513800
PMCPMC6306707
OpenAlexW2903536491

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.