ArticleMolecules (Basel, Switzerland)2018
Mechanochemical Catalytic Transfer Hydrogenation of Aromatic Nitro Derivatives.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 71 citations in OpenAlex.
- Mechanochemical Methods for Amide Bond Formation.Chemical reviews · 2026Review
- Mechanochemical Extrusion for Sustainable Synthesis of Amides and Amines via the Leuckart Reaction.ACS sustainable chemistry & engineering · 2025Article
- Advances in Mechanochemical Methods for One-Pot Multistep Organic Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Synthesis, Solid State Structure, and Cytotoxic Activity of a Complex Dimer of Yttrium with Anthranilic Acid against Cancer Cells.Biological trace element research · 2023Article
- Transfer hydrogenation of nitroarenes using cellulose filter paper-supported Pd/C by filtration as well as sealed methods.RSC advances · 2022Article
- Complementarity of solution and solid state mechanochemical reaction conditions demonstrated by 1,2-debromination of tricyclic imides.Beilstein journal of organic chemistry · 2022Article
- Ammonium Formate-Pd/C as a New Reducing System for 1,2,4-Oxadiazoles. Synthesis of Guanidine Derivatives and Reductive Rearrangement to Quinazolin-4-Ones with Potential Anti-Diabetic Activity.International journal of molecular sciences · 2021Article
- In Situ Stabilisation of Silver Nanoparticles at Chitosan-Functionalised Graphene Oxide for Reduction of 2,4-Dinitrophenol in Water.Polymers · 2021Article
- Mechanochemical P-derivatization of 1,3,5-Triaza-7-Phosphaadamantane (PTA) and Silver-Based Coordination Polymers Obtained from the Resulting Phosphabetaines.Molecules (Basel, Switzerland) · 2020Article
- Direct Mechanocatalysis: Using Milling Balls as Catalysts.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020Review
- Michael Addition Reaction Catalyzed by Imidazolium Chloride to Protect Amino Groups and Construct Medium Ring Heterocycles.Molecules (Basel, Switzerland) · 2019Article
- A solvent-free mechanochemical synthesis of polyaromatic hydrocarbon derivatives.RSC advances · 2019Article
- Mechanochemical Friedel-Crafts acylations.Beilstein journal of organic chemistry · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Mechanochemical ball milling catalytic transfer hydrogenation (CTH) of aromatic nitro compounds using readily available and cheap ammonium formate as the hydrogen source is demonstrated as a simple, facile and clean approach for the synthesis of substituted anilines and selected pharmaceutically relevant compounds. The scope of mechanochemical CTH is broad, as the reduction conditions tolerate various functionalities, for example nitro, amino, hydroxy, carbonyl, amide, urea, amino acid and heterocyclic. The presented methodology was also successfully integrated with other types of chemical reactions previously carried out mechanochemically, such as amide bond formation by coupling amines with acyl chlorides or anhydrides and click-type coupling reactions between amines and iso(thio)cyanates. In this way, we showed that active pharmaceutical ingredients Procainamide and Paracetamol could be synthesized from the respective nitro-precursors on milligram and gram scale in excellent isolated yields.
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