ArticleMolecules (Basel, Switzerland)2018
Investigation of the Effects of Molecular Parameters on the Hemostatic Properties of Chitosan.
Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 83 citations in OpenAlex.
- Modified Chitosan-Based Hemostatic Dressings Incorporating Heparin-Loaded Nanoparticles for Enhanced Hemostatic Activity.Pharmaceutics · 2026Article
- Novel Biological-Based Strategy for Synthesis of Green Nanochitosan and Copper-Chitosan Nanocomposites: Promising Antibacterial and Hematological Agents.Nanomaterials (Basel, Switzerland) · 2024Article
- Cloning and Characterization of Chitin Deacetylase fromInternational journal of molecular sciences · 2024Article
- The Chemical Modification to Improve Solubility of Chitosan and Its Derivatives Application, Preparation Method, Toxicity as a Nanoparticles.Nanotechnology, science and applications · 2024Review
- Chitosan nanoparticle toxicity: A comprehensive literature review ofToxicology reports · 2023Review
- Bacterial-Nanocellulose-Based Biointerfaces and Biomimetic Constructs for Blood-Contacting Medical Applications.ACS materials Au · 2023Review
- Multifunctional Sodium Hyaluronate/Chitosan Foam Used as an Absorbable Hemostatic Material.Bioengineering (Basel, Switzerland) · 2023Article
- Preparation and Surface Characterization of Chitosan-Based Coatings for PET Materials.Molecules (Basel, Switzerland) · 2023Article
- Chitosan-Based Hemostatic Hydrogels: The Concept, Mechanism, Application, and Prospects.Molecules (Basel, Switzerland) · 2023Review
- Expression and Molecular Modification of Chitin Deacetylase fromMolecules (Basel, Switzerland) · 2022Article
- Hemostatic Alginate/Nano-Hydroxyapatite Composite Aerogel Loaded with Tranexamic Acid for the Potential Protection against Alveolar Osteitis.Pharmaceutics · 2022Article
- Progress in Research of Chitosan Chemical Modification Technologies and Their Applications.Marine drugs · 2022Review
- Applications of Chitosan in Surgical and Post-Surgical Materials.Marine drugs · 2022Review
- Application of chitosan-based nanoparticles in skin wound healing.Asian journal of pharmaceutical sciences · 2022Review
- Preparation of Chitosan/Clay Composites for Safe and Effective Hemorrhage Control.Molecules (Basel, Switzerland) · 2022Article
- High-Power Laser Deposition of Chitosan Polymers: Medical and Environmental Applications.Polymers · 2022Article
- Recent advances in biopolymer-based hemostatic materials.Regenerative biomaterials · 2022Review
- Chitosan as an Underrated Polymer in Modern Tissue Engineering.Nanomaterials (Basel, Switzerland) · 2021Review
- Article
- Investigation of the antimicrobial activity and hematological pattern of nano-chitosan and its nano-copper composite.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Hemorrhea is one of the major problems in war, trauma care, and surgical operation that threaten the life of the injured and patients. As a novel polymeric hemostatic agent, biodegradable chitosan can stop bleeding through a variety of approaches. In this paper, chitosan with various molecular parameters was prepared from chitin as raw material through deacetylation, oxidative degradation, hydrophilic modification, and salt formation reactions. The influence of different polymer parameters on the hemostatic effects of chitosan was investigated by in vitro coagulation time and dynamic coagulation assay. The results showed that when the molecular weights were high (10⁵⁻10⁶) and approximate, the coagulation effect of chitosan improved with a decrease of the deacetylation degree and achieved a prominent level in a moderate degree of deacetylation (68.36%). With the same degree of deacetylation, the higher the molecular weight of chitosan, the better the procoagulant effect. The substituent derivatives and acid salts of chitosan showed significant procoagulant effects, especially the acid salts of chitosan. In addition, the hemostasis mechanism of chitosan with various parameters was preliminarily explored by analyzing the plasma recalcification time (PRT). The efforts in this paper laid a basis for further study of the structure⁻activity relationship and the mechanism of chitosan hemostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.