Evidence map›Paper›PMID 30513375›Full record

ArticleNeuroscience2019

Genotype Differences in Sensitivity to the Anticonvulsant Effect of the Synthetic Neurosteroid Ganaxolone during Chronic Ethanol Withdrawal.

Michelle A Nipper, Jeremiah P Jensen, Melinda L Helms, Matthew M Ford, John C Crabbe, David J Rossi, Deborah A Finn

Abstract read
In one paragraph

Article in Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Michelle A NipperDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, United States. Electronic address: nipper@ohsu.edu.
Jeremiah P JensenDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, United States.
Melinda L HelmsDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, United States.
Matthew M FordDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, United States; Division of Neuroscience, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR 97006, United States.
John C CrabbeDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, United States; Portland Alcohol Research Center, VA Portland Health Care System, Portland, OR 97239, United States.
David J RossiDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, United States; Department of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA 99164, United States.
Deborah A FinnDepartment of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, United States; Portland Alcohol Research Center, VA Portland Health Care System, Portland, OR 97239, United States.
Oregon Health & Science University · USOregon National Primate Research Center · US

Funding

Translational measures of risk for excessive alcohol consumptionP60AA010760 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI TAMARA J. PHILLIPS · 2006 to 2026
$34.5M
NEUROSTEROID MODULATION OF ETHANOL WITHDRAWAL SEVERITYR01AA012439 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI FINN, DEBORAH A., ROSSI, DAVID J · 2000 to 2017
$4.6M
Mouse Genetic Models for Alcohol ResearchR24AA020245 · NIAAA · OREGON HEALTH & SCIENCE UNIVERSITY · PI PHILLIPS, TAMARA J. · 2011 to 2020
$2.3M
Cerebellar Contributions to Alcohol Use DisordersR01AA026078 · NIAAA · WASHINGTON STATE UNIVERSITY · PI ROSSI, DAVID J · 2017 to 2021
$1.7M
Genetic Models of AlcoholismI01BX000313 · VA · PORTLAND VA MEDICAL CENTER · PI CRABBE, JOHN C. · 2009 to 2019
–
BLRD VA I01 BX000313NIAAA NIH HHS P60 AA010760NIAAA NIH HHS R01 AA012439NIAAA NIH HHS R01 AA026078NIAAA NIH HHS R24 AA020245NIH HHS P60 AA10760NIH HHS RO1 AA012439
6 · The paper itself

Abstract

Sensitivity to anticonvulsant effects of the γ-aminobutyric acid

Indexed as

Alcohol Withdrawal SeizuresAnimalsAnticonvulsantsFemaleGenetic Predisposition to DiseaseGenotypeMaleMice, Inbred DBAPregnanoloneSex FactorsSpecies SpecificityAnticonvulsantsganaxolonePregnanolonealcoholallopregnanoloneDBA/2J miceGABA(A) receptorssexWithdrawal Seizure-Prone mice

Identifiers

PMID30513375
PMCPMC7079727
OpenAlexW2903290077

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.