Observational studyThe journal of allergy and clinical immunology. In practice2019
Drug Hypersensitivity Reactions Documented in Electronic Health Records within a Large Health System.
Observational study in The journal of allergy and clinical immunology. In practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- The Use of Electronic Health Records to Study Drug-Induced Hypersensitivity Reactions from 2000 to 2021: A Systematic Review.Immunology and allergy clinics of North America · 2022Pooled it
- Opioid Allergy Registrations in Danish Electronic Health Records: A Multihospital Register-Based Study With Journal Audit.Basic & clinical pharmacology & toxicology · 2026Article
- Pharmacogenomics of antibacterial and antiviral therapies: Clinical actionability, evidence gaps, and future directions.Pharmacological reviews · 2026Review
- Hereditary Alpha-Tryptasemia (HαT) as a Risk Modifier for Severe Anaphylaxis.Immunology and allergy clinics of North America · 2026Review
- Accurately describing drug allergies and adverse drug reactions: The Australian Delphi Consensus on Drug Allergy Terminology.The journal of allergy and clinical immunology. Global · 2026Article
- The drug allergy history tool (DAHT): Validation of a patient-reported survey instrument.The Journal of allergy and clinical immunology · 2025Article
- Documentation of DRESS in the allergy list of patients with a prior history of DRESS.The journal of allergy and clinical immunology. In practice · 2025Article
- Adverse Drug Events in Ambulatory Care: A Cross-Sectional Study.Drug safety · 2025Article
- Cephalosporin Allergy: Updates on Diagnostic Testing.Current allergy and asthma reports · 2024Review
- Evaluation of Antibiotic Allergy in the Ambulatory Setting Using a Standardized Questionnaire.Journal of pharmacy practice · 2024Article
- Who is at-risk for severe anaphylaxis in France?The World Allergy Organization journal · 2024Article
- Long-Term Outcomes Associated With β-Lactam Allergies.JAMA network open · 2024Article
- Sociodemographic Characteristics of Adverse Event Reporting in the USA: An Ecologic Study.Drug safety · 2024Article
- Drug-induced hypersensitivity reactions in a Lebanese outpatient population: A decade-long retrospective analysis (2012-2021).The journal of allergy and clinical immunology. Global · 2024Article
- Drug-Induced Anaphylaxis: National Database Analysis.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Fixed Drug Eruptions With Flavoured Liquid Formulations of Over-the-Counter Analgesics: A Case Report.Cureus · 2023Article
- Drug Hypersensitivity Reactions in Patients with Cystic Fibrosis: Potential Value of the Lymphocyte Toxicity Assay to Assess Risk.Molecular diagnosis & therapy · 2023Article
- Incidence and Economic Burden of Adverse Drug Reactions in Hospitalization: A Prospective Study in Korea.Journal of Korean medical science · 2023Article
- Patient Characteristics Associated With Reactions to Mrgprx2-Activating Drugs in an Electronic Health Record-Linked Biobank.The journal of allergy and clinical immunology. In practice · 2023Observational
- A retrospective case-control study to evaluate the use of beta-lactam desensitization in the management of penicillin-allergic patients: a potential strategy for Antimicrobial Stewardship Programs.Frontiers in pharmacology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundHypersensitivity reactions (HSRs) are immunologic responses to drugs. Identification of HSRs documented in the electronic health record (EHR) is important for patient safety.
objectiveTo examine HSR epidemiology using longitudinal EHR data from a large United States health care system.
methodsPatient demographic information and drug allergy data were obtained from the Partners Enterprise-wide Allergy Repository for 2 large tertiary care hospitals from 2000 to 2013. Drug-induced HSRs were categorized into immediate and delayed HSRs based on typical phenotypes. Causative drugs and drug groups were assessed. The prevalence of HSRs was determined, and sex and racial differences were analyzed.
resultsAmong 2.7 million patients, 377,474 (13.8%) reported drug-induced HSRs, of whom 70.3% were female and 77.5% were white. A total of 580,456 HSRs were reported, of which 53.1% were immediate reaction phenotypes. Common immediate HSRs included hives (48.8%), itching (15.0%), and angioedema (14.1%). Delayed HSR phenotypes (46.9%) were largely rash (99.0%). Penicillins were associated with the most immediate (33.0%) and delayed (39.0%) HSRs. Although most HSRs were more prevalent in females and white patients, notable differences were identified for certain rare HSRs including acute interstitial nephritis, which appeared more commonly in males (0.02% vs 0.01%, P < .001). Asian patients had more fixed drug eruptions (0.007% vs 0.002%, P = .021) and severe cutaneous adverse reactions (0.05% vs 0.04%, P < .001).
conclusionsDrug HSRs were reported in 13.8% of patients. Almost one-half of reported immediate HSR phenotypes were hives, and almost all reported delayed HSR phenotypes were rash. HSRs largely affected female and white patients, but differences were identified for specific rare HSRs.
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Registered trials
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