ReviewBrain research2019
Dopamine tunes prefrontal outputs to orchestrate aversive processing.
Review in Brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed.
- Region-specific weighting of sensory intensity and reward prediction error by dopamine signals.iScience · 2026Article
- A dual-pathway dysregulation in prefrontal-habenular circuits mediates stress susceptibility.Nature communications · 2026Article
- Targeting dopamine transporter for treating social transmission of depression-like behaviors in male mice.Nature communications · 2026Article
- POINTseq: Cell-type-specific barcoding reveals single-cell projection architecture of the mouse dopaminergic system.Neuron · 2026Article
- Behavioral change: from neurobiology to behavioral-change theories and back - part 1.Arquivos de neuro-psiquiatria · 2026Review
- Dopamine modulation of aggression.Psychopharmacology · 2026Review
- Cell type-specific barcoding reveals the single-neuron projectional architecture of the mouse midbrain dopaminergic system.bioRxiv : the preprint server for biology · 2026Article
- A prefrontal cortex-lateral hypothalamus circuit controls stress-driven increased food intake.Nature communications · 2026Article
- Dopamine Responses in Medial Frontal Cortex Are More Consistent with a Generalized Arousal Signal Than Signed Reward Prediction Errors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- The Role of the Ventral Tegmental Area in Reward and Addiction: A Comprehensive Review.Neurosciences (Riyadh, Saudi Arabia) · 2026Review
- D1 and D2 neurons in medial nucleus accumbens participate in chronic orofacial pain phenotypes.Pain reports · 2026Article
- Resolving the heterogeneity of dopamine subsystems dysfunction in schizophrenia: a PET meta-analysis.Schizophrenia (Heidelberg, Germany) · 2025Review
- Sex differences in noradrenergic regulation of the medial prefrontal cortex in mice.Biology of sex differences · 2025Article
- Dynamic changes of dopamine neuron activity and plasticity at different stages of negative reinforcement learning.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Dopaminergic projections to the prefrontal cortex are critical for rapid threat avoidance learning.Current biology : CB · 2025Article
- How dopamine guides our social world.Pharmacological reviews · 2025Review
- Alterations in dopaminergic innervation and receptors in focal cortical dysplasia.Brain : a journal of neurology · 2025Article
- Cortical VIP neurons as a critical node for dopamine actions.Science advances · 2025Article
- Cafeteria Diet Abstinence Induces Depressive Behavior and Disrupts Endocannabinoid Signaling in Dopaminergic Areas: A Preclinical Study.Current neuropharmacology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Decades of research suggest that the mesocortical dopamine system exerts powerful control over mPFC physiology and function. Indeed, dopamine signaling in the medial prefrontal cortex (mPFC) is implicated in a vast array of processes, including working memory, stimulus discrimination, stress responses, and emotional and behavioral control. Consequently, even slight perturbations within this delicate system result in profound disruptions of mPFC-mediated processes. Many neuropsychiatric disorders are associated with dysregulation of mesocortical dopamine, including schizophrenia, depression, attention deficit hyperactivity disorder, post-traumatic stress disorder, among others. Here, we review the anatomy and functions of the mesocortical dopamine system. In contrast to the canonical role of striatal dopamine in reward-related functions, recent work has revealed that mesocortical dopamine fine-tunes distinct efferent projection populations in a manner that biases subsequent behavior towards responding to stimuli associated with potentially aversive outcomes. We propose a framework wherein dopamine can serve as a signal for switching mPFC states by orchestrating how information is routed to the rest of the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.