Evidence map›Paper›PMID 30513201›Full record

ArticleBiochemistry2019

Amyloid-like Behavior of Site-Specifically Citrullinated Myelin Oligodendrocyte Protein (MOG) Peptide Fragments inside EBV-Infected B-Cells Influences Their Cytotoxicity and Autoimmunogenicity.

Can Araman, Miriam E van Gent, Nico J Meeuwenoord, Nicole Heijmans, Mikkel H S Marqvorsen, Ward Doelman, Bart W Faber, Bert A 't Hart, Sander I Van Kasteren

Open access · hybridAbstract read
In one paragraph

Article in Biochemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Multiple sclerosis and infection: history, EBV, and the search for mechanism.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  3. EBV infection drives MS pathology: No.Multiple sclerosis (Houndmills, Basingstoke, England) · 2024
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Environmental Influencers, MicroRNA, and Multiple Sclerosis.Journal of central nervous system disease · 2020
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Can AramanLeiden Institute of Chemistry and Institute for Chemical Immunology , Leiden University , Einsteinweg 55 , 2333 CC Leiden , The Netherlands.ORCID 0000-0002-6961-5607
Miriam E van GentLeiden Institute of Chemistry and Institute for Chemical Immunology , Leiden University , Einsteinweg 55 , 2333 CC Leiden , The Netherlands.
Nico J MeeuwenoordLeiden Institute of Chemistry and Department of Bioorganic Synthesis , Leiden University , Einsteinweg 55 , 2333 CC Leiden , The Netherlands.
Nicole HeijmansDepartment of Immunobiology , Biomedical Primate Research Centre , 2288 GJ Rijswijk , The Netherlands.
Mikkel H S MarqvorsenLeiden Institute of Chemistry and Institute for Chemical Immunology , Leiden University , Einsteinweg 55 , 2333 CC Leiden , The Netherlands.
Ward DoelmanLeiden Institute of Chemistry and Institute for Chemical Immunology , Leiden University , Einsteinweg 55 , 2333 CC Leiden , The Netherlands.
Bart W FaberDepartment of Parasitology , Biomedical Primate Research Centre , 2288 GJ Rijswijk , The Netherlands.
Bert A 't HartDepartment of Immunobiology , Biomedical Primate Research Centre , 2288 GJ Rijswijk , The Netherlands.
Sander I Van KasterenLeiden Institute of Chemistry and Institute for Chemical Immunology , Leiden University , Einsteinweg 55 , 2333 CC Leiden , The Netherlands.ORCID 0000-0003-3733-818X
Leiden University · NLBiomedical Primate Research Centre · NLUniversity Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple sclerosis (MS) is an autoimmune disorder manifested via chronic inflammation, demyelination, and neurodegeneration inside the central nervous system. The progressive phase of MS is characterized by neurodegeneration, but unlike classical neurodegenerative diseases, amyloid-like aggregation of self-proteins has not been documented. There is evidence that citrullination protects an immunodominant peptide of human myelin oligodendrocyte glycoprotein (MOG

Indexed as

Amino Acid SequenceAmyloidAmyloidogenic ProteinsAnimalsBenzothiazolesB-LymphocytesCallithrixCell LineCitrullinationDendritic CellsHerpesvirus 4, HumanHumansMice, Inbred C57BLMultiple Sclerosis, Chronic ProgressiveMyelin-Oligodendrocyte GlycoproteinPeptide FragmentsAmyloidAmyloidogenic ProteinsBenzothiazolesMyelin-Oligodendrocyte Glycoproteinmyelin oligodendrocyte glycoprotein (1-125)myelin oligodendrocyte glycoprotein (35-55)Peptide FragmentsRecombinant Proteinsthioflavin T

Identifiers

PMID30513201
PMCPMC6374747
OpenAlexW2902629832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.