ArticlePloS one2018
Plasma endothelin-1 levels are increased in atrial fibrillation patients with hyperthyroidism.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Big Endothelin-1 Predicts the long-term survival in patients undergoing septal myectomy.International journal of cardiology. Heart & vasculature · 2026Article
- Endothelin: A Potential Universal Systemic Biomarker.Current medicinal chemistry · 2026Review
- Coronary microvascular dysfunction, arrythmias, and sudden cardiac death: A literature review.American heart journal plus : cardiology research and practice · 2024Article
- [Serum levels of endothelin-1 and connective tissue growth factor are elevated in patients with atrial fibrillation and correlated with relapse following radiofrequency ablation].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- The bidirectional relationship of thyroid disease and atrial fibrillation: Established knowledge and future considerations.Reviews in endocrine & metabolic disorders · 2022Review
- The role of fish oil in attenuating cardiac oxidative stress, inflammation and fibrosis in rat model of thyrotoxicosis.Heliyon · 2019Article
- Altered profile of circulating microparticles in nonvalvular atrial fibrillation.Clinical cardiology · 2019Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundEndothelin-1 (ET-1) is a potent vasoconstrictor, mitogen and inflammatory factor that may contribute to development of atrial fibrillation (AF). Plasma ET-1 levels are increased in hyperthyroid patients, but studies evaluating its relation to AF development in hyperthyroid patients are lacking.
objectiveThe present study seeks to evaluate the relation of plasma ET-1 to AF development as a function of thyroid status.
methodsBlood samples from euthyroid patients (n = 41), hypothyroid (n = 61), hyperthyroid (n = 41), AF with hyperthyroidism (n = 9), and euthyroid AF (n = 10) patients were collected. Plasma ET-1, CRP, and thyroid hormone levels were measured and compared between groups.
resultsPlasma ET-1 levels were higher in hyperthyroid and euthyroid AF patients> hyperthyroid-non-AF > hypo and euthyroid non-AF patients. Plasma ET-1 levels positively correlated with free T3 and T4 levels, and negatively with TSH levels. By multivariate analysis, plasma ET-1 was positively associated with AF, hyperthyroidism, and age. Plasma CRP did not vary by study group in either univariate or multivariate analyses.
conclusionPlasma ET-1 is associated with AF, elevated in hyperthyroid patients and positively correlated with thyroid hormone levels, suggesting that hyperthyroidism may increase ET-1 expression and release. This study may guide development of novel predictors of AF associated with hyperthyroidism, and may help to personalize therapy in hyperthyroid patients.
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