ArticlePloS one2018
Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS): A cross-sectional study.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- Serum vitamin D levels in non-obese women with polycystic ovary syndrome: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Prevalence and influencing factors of vitamin D deficiency in women with polycystic ovary syndrome: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Influence of vitamin D supplementation on lipid levels in polycystic ovary syndrome patients: a meta-analysis of randomized controlled trials.The Journal of international medical research · 2020Pooled it
- Association of vitamin D receptor gene variants with polycystic ovary syndrome: a meta-analysis.BMC medical genetics · 2019Pooled it
- Synergistic modulation of insulin resistance and ovarian oxidative stress by alpha-lipoic acid and vitamin D in an experimental rat model of polycystic ovary syndrome.Scientific reports · 2026Article
- Beyond Body Mass Index: Re-Examining Vitamin D Deficiency in Infertile Women With PCOS.Health science reports · 2026Article
- Review
- Relations of Insulin Resistance, Body Weight, Vitamin D Deficiency, SHBG and Androgen Levels in PCOS Patients.Biomedicines · 2025Article
- The association of rs7041 polymorphism with infertility and recurrent pregnancy loss in Iranian women with polycystic ovary syndrome.BMC research notes · 2025Article
- Vitamin D in Reproductive Health Disorders: A Narrative Review Focusing on Infertility, Endometriosis, and Polycystic Ovarian Syndrome.International journal of molecular sciences · 2025Review
- Vitamin D deficiency and polycystic ovary syndrome: an opinion and positioning article.Frontiers in nutrition · 2025Article
- Is vitamin D deficiency a more frequent finding in hirsutism or not?Archives of dermatological research · 2024Article
- Menstrual Blood as a Non-Invasive Alternative for Monitoring Vitamin Levels.Journal of clinical medicine · 2024Article
- [Polycystic ovary syndrome: new and promising treatment methods].Problemy endokrinologii · 2024Review
- Causal association between low vitamin D and polycystic ovary syndrome: a bidirectional mendelian randomization study.Journal of ovarian research · 2024Article
- Clinical Phenotypes of PCOS: a Cross-Sectional Study.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Relationship between Serum 25-Hydroxyvitamin D Levels and Hormonal Status in Infertile Women: A Retrospective Study.Diagnostics (Basel, Switzerland) · 2023Article
- Effect of Vitamin DCells · 2023Article
- Influence of Vitamin D on the Incidence of Metabolic Syndrome and Hormonal Balance in Patients with Polycystic Ovary Syndrome.Nutrients · 2023Article
- Multi-omics insights and therapeutic implications in polycystic ovary syndrome: a review.Functional & integrative genomics · 2023Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare vitamin D status in women with PCOS versus fertile women and subsequently evaluate the association between vitamin D status and metabolic disturbances in PCOS women.
methodsWe conducted a cross-sectional comparison study of 639 women with PCOS and 449 fertile women. Serum 25-hydroxyvitamin D (25(OH)D) was stratified into a severe deficient (< 25 nmol/l), insufficient (25-50 nmol/l), moderate (50-75 nmol/l) and adequate (> 75 nmol/l) status. The main outcome measures were the difference in vitamin D status between PCOS and fertile women, and the association between serum 25(OH)D and metabolic disturbances in PCOS women only.
resultsSerum 25(OH)D was significantly lower in PCOS women compared to fertile controls (mean 25(OH)D of 49.0 nmol/l versus 64.5 nmol/l). An adjusted significant difference was seen between serum 25(OH)D and homeostasis model assessment (HOMA-IR) (β = 0.76; 95% CI: 0.63-0.91; p < 0.01), HDL-cholesterol (β = 0.20; 95% CI: 0.05-0.60, p < 0.01) and apolipoprotein A1 (β = 26.2; 95% CI: 7.5-45.0, p < 0.01) between the highest vitamin D group compared to the lowest vitamin D group.
conclusionsThis study demonstrates that women with PCOS have a significantly lower serum 25(OH)D compared to fertile controls. A compromised vitamin D status in PCOS women is associated with a higher HOMA-IR and an unfavourable lipid profile. Large randomized controlled trials are necessary to explore the causality of this linkage.
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Registered trials
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