ArticleThe plant genome2018
Structural Variation, Functional Differentiation, and Activity Correlation of the Cytochrome P450 Gene Superfamily Revealed in Ginseng.
Article in The plant genome, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Genome-Wide Identification and Characterization of theInternational journal of molecular sciences · 2026Article
- Genome-wide identification and expression analysis ofPhysiology and molecular biology of plants : an international journal of functional plant biology · 2025Article
- Evolution, Structural and Functional Characteristics of thePlants (Basel, Switzerland) · 2024Article
- Comprehensive Review on Plant Cytochrome P450 Evolution: Copy Number, Diversity, and Motif Analysis From Chlorophyta to Dicotyledoneae.Genome biology and evolution · 2024Review
- Genome and transcriptome analysis to understand the role diversification of cytochrome P450 gene under excess nitrogen treatment.BMC plant biology · 2021Article
- Androgen-Binding Protein (Abp) Evolutionary History: Has Positive Selection Caused Fixation of Different Paralogs in Different Taxa of the Genus Mus?Genome biology and evolution · 2021Article
- Chemical components of ginseng, their biotransformation products and their potential as treatment of hypertension.Molecular and cellular biochemistry · 2021Review
- Spatial protein expression ofJournal of ginseng research · 2021Article
- Genome-wide survey of sucrose non-fermenting 1-related protein kinase 2 in Rosaceae and expression analysis of PbrSnRK2 in response to ABA stress.BMC genomics · 2020Article
- The bHLH gene family and its response to saline stress in Jilin ginseng, Panax ginseng C.A. Meyer.Molecular genetics and genomics : MGG · 2020Article
- Recent Advances in the Metabolic Engineering of Yeasts for Ginsenoside Biosynthesis.Frontiers in bioengineering and biotechnology · 2020Review
- Article
- Article
- Transcriptome analysis identifies strong candidate genes for ginsenoside biosynthesis and reveals its underlying molecular mechanism in Panax ginseng C.A. Meyer.Scientific reports · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ginseng ( C.A. Mey.) is one of the most important medicinal herbs for human health and medicine, for which ginsenosides are the major bioactive components. The cytochrome P450 genes, , form a large gene superfamily; however, only three genes have been identified from ginseng and shown to be involved in ginsenoside biosynthesis, indicating the importance of the gene superfamily in the process. Here we report genome-wide identification and systems analysis of the genes in ginseng, defined as genes. We identified 414 genes, including the three published genes. These genes formed a superfamily consisting of 41 gene families, with a substantial diversity in phylogeny and dramatic variation in spatiotemporal expression. Gene ontology (GO) analysis categorized the gene superfamily into 12 functional subcategories distributing among all three primary functional categories, suggesting its functional differentiation. Nevertheless, the majority of its gene members expressed correlatively and tended to form a coexpression network and some of them were commonly regulated in expression across tissues and developmental stages. These results have led to genome-wide identification of genes useful for genome-wide identification of the genes involved in ginsenoside biosynthesis in ginseng and provided the first insight into how a gene superfamily functionally differentiates and acts correlatively in plants.
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