ArticleJournal of musculoskeletal & neuronal interactions2018
Upward running is more beneficial than level surface or downslope running in reverting tibia bone degeneration in ovariectomized rats.
Article in Journal of musculoskeletal & neuronal interactions, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 2 citations in OpenAlex.
- The effects of combined endurance training of different intensities and resistance training on bone mineral density, microstructure and mechanical properties of rats.Frontiers in endocrinology · 2026Article
- Effects of different running intensities on the micro-level failure strain of rat femoral cortical bone structures: a finite element investigation.Biomedical engineering online · 2023Article
- Exercise and Diet: Uncovering Prospective Mediators of Skeletal Fragility in Bone and Marrow Adipose Tissue.Current osteoporosis reports · 2020Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveWe investigated the effects of upslope, level surface, and downslope running on indices of tibia and femur bone recovery in ovariectomized (OVX) rats.
methodsRats were randomly divided into five groups: one sham-operated (SHAM) group and four OVX groups. One OVX group was a non-running control (OVX-Cont) and the others performed upslope running (OVX-Up), level surface running (OVX-Level), or downslope running (OVX-Down) on a treadmill after ovariectomy. The metaphysis region of the proximal tibia, distal femur, and proximal femur were scanned by micro-computed tomography and various geometric and microarchitectural parameters as well as bone mineral density measured using bone analysis software.
resultsTibial bone geometric parameters, BV/TV and trabecular thickness, were significantly improved in OVX-Up and OVX-Level groups compared to that in OVX-Cont and OVX-Down groups, and improved to a greater degree in OVX-Up group than in OVX-Level group.
conclusionsTherefore, running slope substantially influences the beneficial effects of treadmill running on OVX-induced bone degeneration, with upward running being more effective than level surface running or downslope running, likely due to the greater bone loads associated with upslope running. The benefits of upslope treadmill running were particularly observed in the proximal tibia.
Indexed as
Identifiers
30511953PMC6313044W3009271901What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.