Evidence map›Paper›PMID 30511833›Full record

ReviewChemical reviews2019

Inorganic Complexes and Metal-Based Nanomaterials for Infectious Disease Diagnostics.

Christine F Markwalter, Andrew G Kantor, Carson P Moore, Kelly A Richardson, David W Wright

Abstract readReview
In one paragraph

Review in Chemical reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. External Stimuli-Activable Single-Atom Nanozymes for Bioapplications.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Ultrasensitive Detection of Biomarkers in a Color-Switchable Microcavity-Reactor Laser.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Article
  16. Review
  17. Article
  18. Review
  19. Characterization and utility of immobilized metal affinity-functionalized cellulose membranes for point-of-care malaria diagnostics.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2021
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christine F MarkwalterDepartment of Chemistry , Vanderbilt University , Nashville , Tennessee 37235 , United States.
Andrew G KantorDepartment of Chemistry , Vanderbilt University , Nashville , Tennessee 37235 , United States.
Carson P MooreDepartment of Chemistry , Vanderbilt University , Nashville , Tennessee 37235 , United States.
Kelly A RichardsonDepartment of Chemistry , Vanderbilt University , Nashville , Tennessee 37235 , United States.
David W WrightDepartment of Chemistry , Vanderbilt University , Nashville , Tennessee 37235 , United States.ORCID 0000-0002-1415-9931

Funding

Vanderbilt-Zambia Network for Innovation in Global Health TechnologiesD43TW009348 · FIC · VANDERBILT UNIVERSITY · PI HASELTON, FREDERICK R, HEIMBURGER, DOUGLAS CORBETT · 2012 to 2016
$1.7M
A 100-fold more sensitive TB diagnostic based on magnetic concentration and "coffee ring" formationR01AI135937 · NIAID · VANDERBILT UNIVERSITY · PI BLACKBURN, JONATHAN MICHAEL, HASELTON, FREDERICK R · 2017 to 2021
$1.7M
Mobile Health and Treat (mHAT) for Malaria EliminationR21TW010635 · FIC · VANDERBILT UNIVERSITY · PI WRIGHT, DAVID W · 2017 to 2018
$376k
FIC NIH HHS D43 TW009348FIC NIH HHS R21 TW010635NIAID NIH HHS R01 AI135937
6 · The paper itself

Abstract

Infectious diseases claim millions of lives each year. Robust and accurate diagnostics are essential tools for identifying those who are at risk and in need of treatment in low-resource settings. Inorganic complexes and metal-based nanomaterials continue to drive the development of diagnostic platforms and strategies that enable infectious disease detection in low-resource settings. In this review, we highlight works from the past 20 years in which inorganic chemistry and nanotechnology were implemented in each of the core components that make up a diagnostic test. First, we present how inorganic biomarkers and their properties are leveraged for infectious disease detection. In the following section, we detail metal-based technologies that have been employed for sample preparation and biomarker isolation from sample matrices. We then describe how inorganic- and nanomaterial-based probes have been utilized in point-of-care diagnostics for signal generation. The following section discusses instrumentation for signal readout in resource-limited settings. Next, we highlight the detection of nucleic acids at the point of care as an emerging application of inorganic chemistry. Lastly, we consider the challenges that remain for translation of the aforementioned diagnostic platforms to low-resource settings.

Indexed as

BiomarkersCommunicable DiseasesCoordination ComplexesHumansLuminescent MeasurementsMagneticsMetalsNanostructuresPoint-of-Care SystemsBiomarkersCoordination ComplexesMetals

Identifiers

PMID30511833
PMCPMC6348445

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.