Evidence map›Paper›PMID 30511787›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2019

Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1

Jørn Eivind Tungen, Lisa Gerstmann, Anders Vik, Roberta De Matteis, Romain Alexandre Colas, Jesmond Dalli, Nan Chiang, Charles Nicholas Serhan, Markus Kalesse, Trond Vidar Hansen

Erratum issuedAbstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. RvD1International journal of molecular sciences · 2022
    Article
  9. Expression and function of resolvin RvD1European journal of oral sciences · 2022
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. The First Total Synthesis of the Lipid Mediator PD2Journal of natural products · 2020
    Article
  16. Review
  17. Stereoselective synthesis of MaR2Tetrahedron letters · 2020
    Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jørn Eivind TungenDepartment of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, PO Box 1068, 0316, Oslo, Norway.ORCID http://orcid.org/0000-0002-6522-9661
Lisa GerstmannDepartment of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, PO Box 1068, 0316, Oslo, Norway.
Anders VikDepartment of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, PO Box 1068, 0316, Oslo, Norway.ORCID http://orcid.org/0000-0002-7864-3271
Roberta De MatteisLipid Mediator Unit, Center for Biochemical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Romain Alexandre ColasLipid Mediator Unit, Center for Biochemical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.
Jesmond DalliLipid Mediator Unit, Center for Biochemical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK.ORCID http://orcid.org/0000-0001-6328-3640
Nan ChiangCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115, USA.ORCID http://orcid.org/0000-0003-1963-1585
Charles Nicholas SerhanCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115, USA.ORCID http://orcid.org/0000-0003-4627-8545
Markus KalesseInstitute for Organic Chemistry, Leibniz University Hannover, Schneiderberg 1B, 30167 Hannover and Centre of Biomolecular Drug Research (BMWZ), Schneiderberg 38, 30167 Hannover (Germany), Helmholtz Centre for Infection Research GmbH (HZI), Inhoffenstraße 7, 38124, Braunschweig, Germany.ORCID http://orcid.org/0000-0003-4858-3957
Trond Vidar HansenDepartment of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, PO Box 1068, 0316, Oslo, Norway.ORCID http://orcid.org/0000-0001-5239-9920

Funding

Resolution Mechanisms in Acute Inflammation: Resolution PharmacologyP01GM095467 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI SERHAN, CHARLES NICHOLAS · 2011 to 2020
$14.8M
Barts and The London School of Medicine and Dentistry MGU0343European Cooperation in Science and Technology CM1407FP7 Ideas: European Research Council 677542National Institutes of Health PO1GM095467NIGMS NIH HHS P01 GM095467Norges Forskningsråd FRIPRO-FRINATEK 230470Wellcome TrustWellcome Trust 107613/Z/15/Z
6 · The paper itself

Abstract

New drugs that can resolve inflammation without immunosuppressive effects are at the medicinal chemistry frontier. Pro-resolving endogenously formed small molecules, that is, the resolvins, are excellent candidates displaying such bioactions. The first total synthesis of the specialized pro-resolving mediator RvD1

Indexed as

AnimalsAnti-Inflammatory AgentsDocosahexaenoic AcidsFatty Acids, UnsaturatedHumansInflammationMacrophagesNeutrophilsQuantum TheoryReceptors, G-Protein-CoupledStereoisomerismAnti-Inflammatory AgentsDocosahexaenoic Acidsdocosapentaenoic acidFatty Acids, UnsaturatedGPR32 protein, humanReceptors, G-Protein-Coupledresolvin D1Karstedt's catalystnatural productssp3-sp3 cross-couplingspecialized pro-resolving mediatorstotal synthesis

Identifiers

PMID30511787
PMCPMC6368681

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.