Evidence map›Paper›PMID 30511526›Full record

ArticleZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences2018

[Vitamin D3 regulates mononuclear phagocyte polarization induced by serum from patients with ankylosing spondylitis].

Shengnan Wang, Wang Lyu, Suxian Lin, Yang Lu, Jianchang Jiang, Xiaochun Zhu

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Article in Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Shengnan WangDepartment of Rheumatism and Immunology, Wenzhou Third Clinical Institute of Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou 325000, Zhejiang Province, China.
Wang LyuDepartment of Rheumatism and Immunology, Wenzhou Third Clinical Institute of Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou 325000, Zhejiang Province, China.
Suxian LinDepartment of Rheumatism and Immunology, Wenzhou Third Clinical Institute of Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou 325000, Zhejiang Province, China.
Yang LuDepartment of Rheumatism and Immunology, Wenzhou Third Clinical Institute of Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou 325000, Zhejiang Province, China.
Jianchang JiangDepartment of Rheumatism and Immunology, Wenzhou Third Clinical Institute of Wenzhou Medical University, Wenzhou People's Hospital, Wenzhou 325000, Zhejiang Province, China.
Xiaochun ZhuDepartment of Rheumatism and Immunology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effect of vitamin D3 on polarization of monocyte macrophages induced by serum from patients with ankylosing spondylitis (AS).

methodsTwenty AS naïve patients and 20 healthy controls from Wenzhou People's Hospital during January 2016 and December 2017 were enrolled. The macrophages were differentiated from THP1 cells induced by phorbol 12-myristate 13-acetate (PMA), and then co-cultured with the serum from healthy subjects (control group) or AS patients. Vitamin D3 was added in the medium mixed with serum from AS patients. Flow cytometry was used to analyze the ratio of CD68 and CD206 positive cells, and RT-PCR was performed to detect the mRNA expression of inducible nitric oxide synthase(iNOS) and arginase-1(Arg-1).

resultsTHP1 cells could be polarized into mononuclear-macrophages with the induction of PMA. The proportion of CD206 positive cells in AS-serum group was lower than that in the control group (

conclusionsVitamin D3 can regulate the polarization of mononuclear macrophages for immunoregulation in patients with AS.

Indexed as

CholecalciferolMonocytesSpondylitis, AnkylosingAdjuvants, ImmunologicCell DifferentiationHumansAdjuvants, ImmunologicCholecalciferol

Identifiers

PMID30511526
PMCPMC10393693

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