ReviewObesity reviews : an official journal of the International Association for the Study of Obesity2018
Regulation of intestinal growth in response to variations in energy supply and demand.
Review in Obesity reviews : an official journal of the International Association for the Study of Obesity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Physical activity promotes gut adaptation, nutrient responsiveness, and sensitivity to gut peptides in male mice.EBioMedicine · 2026Article
- Mating regulates growth, metabolism, and digestive efficiency in the femaleProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Effects of graded calorie restriction: XXII. Impact of long-term graded calorie restriction on tissue partitioning, digestive efficiency, bone health, and coordination in male C57BL/6J mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Food insecurity promotes adiposity in mice.Obesity (Silver Spring, Md.) · 2025Article
- Interaction between energy level and starch:fat ratio on intestinal energy metabolism of layer pullets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Sex-specific effects of dietary restriction on physiological variables in Japanese quails.Ecology and evolution · 2024Article
- The effect of aging on glucose metabolism improvement after Roux-en-Y gastric bypass in type 2 diabetes rats.Nutrition & diabetes · 2022Article
- Effects of Housing and Management Systems on the Growth, Immunity, Antioxidation, and Related Physiological and Biochemical Indicators of Donkeys in Cold Weather.Animals : an open access journal from MDPI · 2022Article
- Cold Exposure Drives Weight Gain and Adiposity following Chronic Suppression of Brown Adipose Tissue.International journal of molecular sciences · 2022Article
- Chestnut tannins in broiler diets: Affecting intestinal development in different feeding phases.Frontiers in veterinary science · 2022Article
- Heat Stress-Mediated Activation of Immune-Inflammatory Pathways.Antibiotics (Basel, Switzerland) · 2021Review
- Diurnal changes in the murine small intestine are disrupted by obesogenic Western Diet feeding and microbial dysbiosis.Scientific reports · 2021Article
- Discovering signaling mechanisms governing metabolism and metabolic diseases with Drosophila.Cell metabolism · 2021Review
- Liraglutide Activates Type 2 Deiodinase and Enhances β3-Adrenergic-Induced Thermogenesis in Mouse Adipose Tissue.Frontiers in endocrinology · 2021 · on this mapArticle
- Effects of dietary iron level on growth performance, hematological status, and intestinal function in growing-finishing pigs.Journal of animal science · 2021Article
- Changes of Resting Energy Expenditure in Type 2 Diabetes Rats After Roux-en-Y Gastric Bypass.Obesity surgery · 2020Article
- Determination of butyric acid dosage based on clinical and experimental studies - a literature review.Przeglad gastroenterologiczny · 2020Review
- Regulation of intestinal growth in response to variations in energy supply and demand.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The growth of the intestine requires energy, which is known to be met by catabolism of ingested nutrients. Paradoxically, during whole body energy deficit including calorie restriction, the intestine grows in size. To understand how and why this happens, we reviewed data from several animal models of energetic challenge. These were bariatric surgery, cold exposure, lactation, dietary whey protein intake and calorie restriction. Notably, these challenges all reduced the adipose tissue mass, altered hypothalamic neuropeptide expression and increased intestinal size. Based on these data, we propose that the loss of energy in the adipose tissue promotes the growth of the intestine via a signalling mechanism involving the hypothalamus. We discuss possible candidates in this pathway including data showing a correlative change in intestinal (ileal) expression of the cyclin D1 gene with adipose tissue mass, adipose derived-hormone leptin and hypothalamic expression of leptin receptor and the pro-opiomelanocortin gene. The ability of the intestine to grow in size during depletion of energy stores provides a mechanism to maximize assimilation of ingested energy and in turn sustain critical functions of tissues important for survival.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.