Evidence map›Paper›PMID 30511391›Full record

ReviewThe Journal of pathology2019

Melanoma subtypes: genomic profiles, prognostic molecular markers and therapeutic possibilities.

Roy Rabbie, Peter Ferguson, Christian Molina-Aguilar, David J Adams, Carla D Robles-Espinoza

Abstract readReview
In one paragraph

Review in The Journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers.

0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

125 citing papers in PubMed.

  1. Article
  2. Molecular pathology in the diagnosis of cutaneous melanoma.Pathologie (Heidelberg, Germany) · 2026
    Review
  3. Article
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  7. Article
  8. Article
  9. Review
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  12. Article
  13. Review
  14. Ancestry and somatic profile predict acral melanoma origin and prognosis.medRxiv : the preprint server for health sciences · 2025
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

65 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Roy RabbieExperimental Cancer Genetics, The Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0002-9195-5659
Peter FergusonTissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.
Christian Molina-AguilarLaboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Santiago de Querétaro, Mexico.
David J AdamsExperimental Cancer Genetics, The Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0001-9490-0306
Carla D Robles-EspinozaExperimental Cancer Genetics, The Wellcome Sanger Institute, Hinxton, UK.ORCID 0000-0003-3277-7466

Funding

Wellcome Trust
6 · The paper itself

Abstract

Melanoma is characterised by its ability to metastasise at early stages of tumour development. Current clinico-pathologic staging based on the American Joint Committee on Cancer criteria is used to guide surveillance and management in early-stage disease, but its ability to predict clinical outcome has limitations. Herein we review the genomics of melanoma subtypes including cutaneous, acral, uveal and mucosal, with a focus on the prognostic and predictive significance of key molecular aberrations. © 2018 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

Indexed as

Gene Expression Regulation, NeoplasticGenes, cdcHumansMelanomaMutationProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-rafSkin NeoplasmsBRAF protein, humanProto-Oncogene Proteins B-rafProto-Oncogene Proteins c-raf31-gene expression profileacralbiomarkerscutaneousdesmoplasticdriver genesmelanomamucosalmutationspredictiveprognosticuveal

Identifiers

PMID30511391
PMCPMC6492003

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.