Evidence map›Paper›PMID 30511280›Full record

ArticleJournal of digital imaging2019

Toward Automatic Detection of Radiation-Induced Cerebral Microbleeds Using a 3D Deep Residual Network.

Yicheng Chen, Javier E Villanueva-Meyer, Melanie A Morrison, Janine M Lupo

Erratum issuedAbstract read
In one paragraph

Article in Journal of digital imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Deep learning in MRI-guided radiation therapy: A systematic review.Journal of applied clinical medical physics · 2024
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  7. Automated Detection of Cerebral Microbleeds on Two-dimensional Gradient-recalled Echo T2* Weighted Images Using a Morphology Filter Bank and Convolutional Neural Network.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Yicheng ChenUCSF-UC Berkeley Graduate Program in Bioengineering, San Francisco, USA.ORCID 0000-0002-2531-8002
Javier E Villanueva-MeyerDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
Melanie A MorrisonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
Janine M LupoUCSF-UC Berkeley Graduate Program in Bioengineering, San Francisco, USA. Janine.Lupo@ucsf.edu.

Funding

MICROBLEEDS AS A MARKER OF RADIATION-INDUCED BRAIN INJURY IN PEDIATRIC PATIENTSR01HD079568 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LUPO, JANINE MARIE · 2015 to 2019
$2.5M
NICHD NIH HHS R01 HD079568
6 · The paper itself

Abstract

Cerebral microbleeds, which are small focal hemorrhages in the brain that are prevalent in many diseases, are gaining increasing attention due to their potential as surrogate markers of disease burden, clinical outcomes, and delayed effects of therapy. Manual detection is laborious and automatic detection and labeling of these lesions is challenging using traditional algorithms. Inspired by recent successes of deep convolutional neural networks in computer vision, we developed a 3D deep residual network that can distinguish true microbleeds from false positive mimics of a previously developed technique based on traditional algorithms. A dataset of 73 patients with radiation-induced cerebral microbleeds scanned at 7 T with susceptibility-weighted imaging was used to train and evaluate our model. With the resulting network, we maintained 95% of the true microbleeds in 12 test patients and the average number of false positives was reduced by 89%, achieving a detection precision of 71.9%, higher than existing published methods. The likelihood score predicted by the network was also evaluated by comparing to a neuroradiologist's rating, and good correlation was observed.

Indexed as

BrainCerebral HemorrhageHumansImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance ImagingNeural Networks, ComputerRadiation InjuriesReproducibility of ResultsAutomated-detectionCerebral microbleedsConvolutional neural networksDeep learningSusceptibility-weighted imaging

Identifiers

PMID30511280
PMCPMC6737152

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.