ArticleNaunyn-Schmiedeberg's archives of pharmacology2019
Impact of elastin-derived VGVAPG peptide on bidirectional interaction between peroxisome proliferator-activated receptor gamma (Pparγ) and beta-galactosidase (β-Gal) expression in mouse cortical astrocytes in vitro.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Interaction Between Aging-Related Elastin-Derived Peptide (VGVAPG) and Sirtuin 2 and its Impact on Functions of Human Neuron Cells in an In Vitro Model.Molecular neurobiology · 2025Article
- Safety and effects of scorpion-derived antimicrobial peptides as an alternative to antibiotic growth promoters in broilers: growth performance, immune function, and intestinal development.Frontiers in veterinary science · 2025Article
- The Involvement of Glial Cells in Blood-Brain Barrier Damage in Neuroimmune Diseases.International journal of molecular sciences · 2024Review
- Elastin-derived peptides (EDPs) as a potential pro-malignancy factor in human leukemia cell lines.Immunologic research · 2024Article
- Review
- A multimodal imaging study to highlight elastin-derived peptide pro-tumoral effect in a pancreatic xenograft model.British journal of cancer · 2023Article
- Elastin-Derived Peptides in the Central Nervous System: Friend or Foe.Cellular and molecular neurobiology · 2022Review
- Understanding Acquired Brain Injury: A Review.Biomedicines · 2022Review
- Naturally Occurring Antioxidant Therapy in Alzheimer's Disease.Antioxidants (Basel, Switzerland) · 2022Review
- Elastin-derived peptide VGVAPG decreases differentiation of mouse embryo fibroblast (3T3-L1) cells into adipocytes.Adipocyte · 2020Article
- Regulation of cellular senescence by extracellular matrix during chronic fibrotic diseases.Clinical science (London, England : 1979) · 2020Review
- Lactosylceramide induced by elastin-derived peptides decreases adipocyte differentiation.Journal of physiology and biochemistry · 2020Article
- Elastin-Derived Peptide VGVAPG Affects Production and Secretion of Testosterone in Mouse Astrocyte In Vitro.Neurochemical research · 2020Article
- The Elastin-Derived Peptide VGVAPG Does Not Activate the Inflammatory Process in Mouse Cortical Astrocytes In Vitro.Neurotoxicity research · 2020Article
- Specific role of N-methyl-D-aspartate (NMDA) receptor in elastin-derived VGVAPG peptide-dependent calcium homeostasis in mouse cortical astrocytes in vitro.Scientific reports · 2019Article
- Aggravation of Cerebral Ischemia/Reperfusion Injury by Peroxisome Proliferator-Activated Receptor-Gamma Deficiency via Endoplasmic Reticulum Stress.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
- Antiproliferative Effect of Elastin-Derived Peptide VGVAPG on SH-SY5Y Neuroblastoma Cells.Neurotoxicity research · 2019Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The process of degradation of the elastin-rich extracellular matrix produces elastin-derived peptides (EDPs). Different types of EDPs are detectable in the cerebrospinal fluid in healthy individuals and in patients after ischemic stroke. To date, it has been demonstrated that EDPs can regulate the development of insulin resistance in mice in a peroxisome proliferator-activated receptor gamma (Pparγ)-dependent manner. Therefore, the aim of this study was to investigate the impact of the elastin-derived valine-glycine-valine-alanine-proline-glycine (VGVAPG) peptide on Pparγ and beta-galactosidase (β-Gal) expression in mouse cortical astrocytes in vitro. Primary astrocytes were maintained in DMEM/F12 without phenol red supplemented with 10% fetal bovine serum. The cells were exposed to 50 nM, 1 and 50 μM of the VGVAPG peptide. After 3 and 6 h (for mRNA) and 24 and 48 h (for the protein) of exposition to the peptide, the expression of Pparγ and β-Gal was measured. Moreover, the siRNA gene knockdown method was applied. Our study showed, for the first time, that the VGVAPG peptide affected β-Gal and Pparγ mRNA and protein expression in mouse astrocytes in vitro. Furthermore, we suggested a bidirectional interaction between Pparγ and β-Gal. Both pioglitazone and rosiglitazone increased β-Gal and Pparγ protein expression in mouse astrocytes in vitro, and this effect was reduced by the VGVAPG peptide. However, due to the lack of sufficient data explaining the molecular mechanism of action of the VGVAPG peptide in the nervous system, more studies are necessary in this field.
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