Evidence map›Paper›PMID 30511252›Full record

ArticlePurinergic signalling2019

Impact of genetic variations in ADORA2A gene on depression and symptoms: a cross-sectional population-based study.

Sílvia Oliveira, Ana Paula Ardais, Clarissa Ribeiro Bastos, Marta Gazal, Karen Jansen, Luciano de Mattos Souza, Ricardo Azevedo da Silva, Manuella Pinto Kaster, Diogo Rizzato Lara, Gabriele Ghisleni

Open access · bronzeAbstract read
In one paragraph

Article in Purinergic signalling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Adenosine AJournal of neurochemistry · 2026
    Article
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  6. Review
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  9. Psychiatric Symptoms in Wilson's Disease-Consequence ofInternational journal of molecular sciences · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Lateral septum adenosine ANature communications · 2023
    Article
  14. Article
  15. Striatopallidal adenosine ANeuropharmacology · 2023
    Review
  16. Article
  17. Peripheral Expression ofPsychiatry and clinical psychopharmacology · 2023
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sílvia OliveiraDepartment of Life and Health Sciences, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Ana Paula ArdaisDepartment of Life and Health Sciences, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil. ardais@gmail.com.ORCID 0000-0002-7661-5605
Clarissa Ribeiro BastosDepartment of Life and Health Sciences, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Marta GazalDepartment of Life and Health Sciences, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Karen JansenDepartment of Life and Health Sciences, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Luciano de Mattos SouzaDepartment of Life and Health Sciences, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Ricardo Azevedo da SilvaDepartment of Life and Health Sciences, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Manuella Pinto KasterDepartment of Biochemistry, Federal University of Santa Catarina, Florianópolis, Santa Catarina, Brazil.
Diogo Rizzato LaraDepartment of Cellular and Molecular Biology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Gabriele GhisleniDepartment of Life and Health Sciences, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Universidade Católica de Pelotas · BRPontifícia Universidade Católica do Rio Grande do Sul · BRUniversidade Federal de Santa Catarina · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genetic variants involved in adenosine metabolism and its receptors were associated with increased risk for psychiatric disorders, including anxiety, depression, and schizophrenia. Here, we examined an association between a single nucleotide polymorphism in A

Indexed as

AdolescentAdultCross-Sectional StudiesDepressionFemaleGenetic Predisposition to DiseaseGenotypeHumansMalePolymorphism, Single NucleotideReceptor, Adenosine A2AYoung AdultADORA2A protein, humanReceptor, Adenosine A2AAdenosine receptorDepressionDepressive symptomsPolymorphism

Identifiers

PMID30511252
PMCPMC6439088
OpenAlexW2903554947

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.