ArticleEuropean radiology2019
Conventional MR and diffusion-weighted imaging of musculoskeletal soft tissue malignancy: correlation with histologic grading.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it.
- MRI findings for differentiating benign and malignant soft tissue tumors: a systematic review-part 2: key imaging findings.Skeletal radiology · 2026Pooled it
- Apparent diffusion coefficient metrics for treatment response assessment in soft tissue sarcoma: Reproducibility and prognostic value of whole-tumor and sub-regional analysis.Skeletal radiology · 2026Article
- MRI findings for differentiating benign and malignant soft tissue tumors: a narrative review- Part 1: diagnostic performance.Skeletal radiology · 2026Review
- Correlation of apparent diffusion coefficient, FAP expression in IHC and [EJNMMI research · 2026Article
- Diffusion-Weighted Imaging in the Musculoskeletal System: Evolving Role in Modern Imaging Practice.Diagnostics (Basel, Switzerland) · 2026Review
- MRI analysis of undifferentiated pleomorphic sarcoma: correlating imaging features with histological grade.Quantitative imaging in medicine and surgery · 2026Article
- Evaluation of magnetic resonance imaging parameters and compliance with guidelines in soft tissue sarcomas.BMC cancer · 2026Article
- Automated detection of primary soft tissue sarcomas of the extremities using artificial intelligence and ChatGPT.Frontiers in oncology · 2026Article
- Diagnostic values of diffusion-weighted imaging and dynamic contrast-enhanced MRI in the pathological grading of adenoid cystic carcinoma.BMC medical imaging · 2025Article
- Soft-tissue sarcoma: modified grading method improves the accuracy of preoperative MRI in predicting patient outcomes.European radiology · 2025Article
- Identification of superficial invasive and indolent lymphomatous lymph nodes by multiple ultrasonographic vascular imaging.Scientific reports · 2025Article
- Review
- Research on application of multiparametric MRI to predict FNCLCC grading and ki67 expression in soft tissue sarcoma biopsy pathology: Based on a CT-MRI fusion image registration method.Frontiers in oncology · 2025Article
- Diagnostic utility of MRI-based convolutional neural networks in soft tissue sarcomas: a mini-review.Frontiers in oncology · 2025Review
- Multimodality high-frequency ultrasound in the evaluation of cervical malignant lymphoma before biopsy.Future oncology (London, England) · 2024Article
- Predicting the Malignancy Grade of Soft Tissue Sarcomas on MRI Using Conventional Image Reading and Radiomics.Diagnostics (Basel, Switzerland) · 2024Article
- Qualitative and quantitative MRI analysis of alveolar soft part sarcoma: correlation with histological grade and Ki-67 expression.Insights into imaging · 2024Article
- Coefficient of variation of T2-weighted MRI may predict the prognosis of malignant peripheral nerve sheath tumor.Skeletal radiology · 2024Article
- Diffuse-Type Tenosynovial Giant Cell Tumor: What Are the Important Findings on the Initial and Follow-Up MRI?Cancers · 2024Review
- Segmentation model of soft tissue sarcoma based on self-supervised learning.Frontiers in oncology · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate proven soft tissue musculoskeletal malignancies blinded to their Fédération Nationale des Centres de Lutte Contre le Cancer histologic grades to identify the predictive values of conventional MR findings and best fit region of interest (ROI) apparent diffusion coefficient (ADC) measurements. MATERIALS AND
methodsFifty-one consecutive patients with different histologic grades were evaluated by four readers (R1-4) of different experience levels. Quantitatively, the maximum longitudinal size, tumor to muscle signal intensity ratios, and ADC measurements and, qualitatively, the spatial location of the tumor, its signal alterations, heterogeneity, intralesional hemorrhage or fat, and types of enhancement were assessed. Intraclass correlation, weighted kappa, ANOVA, and Fisher exact tests were used.
resultsThere were 22/51 (43%) men (mean age ± SD = 52 ± 16 years) and 29/51 (57%) women (mean age ± SD = 54± 17 years), with the majority of tumors 38/51 (75%) in the lower extremities. Histologic grades were I in 8/51 (16%), II in 17/51 (33%), and III in 26/51 (51%), respectively. The longitudinal dimensions were different among three grades (p = 0.0015), largest with grade I. More central enhancements and deep locations were seen in grade III tumors (p = 0.0191, 0.0246). The ADC mean was significantly lower in grade III than in grade I or II (p < 0.0001 and p = 0.04). The ADC min was significantly lower in grade III than in grade I (p = 0.02). Good to excellent agreements were seen for T1/T2 tumor/muscle ratios, longitudinal dimension, and ADC (ICC = 0.60-0.98).
conclusionLongitudinal tumor dimension, central enhancement, and ADC values differentiate histology grades in musculoskeletal soft tissue malignancy with good to excellent inter-reader reliability. KEY POINTS: • The longitudinal tumor dimension of grade III malignancy is smaller than that of grade I (p < 0.0001), and higher-grade tumors are located deeper (p = 0.0246). • The ADC mean is significantly lower in grade III than in grade I or grade II (p < 0.0001 and p = 0.04). • The ADC minimum is significantly lower in grade III than in grade I (p = 0.02).
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