Evidence map›Paper›PMID 30511134›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2019

Do Stage I Colorectal Cancers with Lymphatic Invasion Require a Different Postoperative Approach?

Lieve G J Leijssen, Anne M Dinaux, Hiroko Kinutake, Liliana G Bordeianou, David L Berger

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Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Risk factors of recurrence in TNM stage I colorectal cancer.Annals of surgical treatment and research · 2023
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lieve G J LeijssenDepartment of General and Gastrointestinal Surgery, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA, 02114, USA.
Anne M DinauxDepartment of General and Gastrointestinal Surgery, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA, 02114, USA.
Hiroko KinutakeDepartment of General and Gastrointestinal Surgery, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA, 02114, USA.
Liliana G BordeianouDepartment of General and Gastrointestinal Surgery, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA, 02114, USA.
David L BergerDepartment of General and Gastrointestinal Surgery, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, Boston, MA, 02114, USA. dberger@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough stage I colorectal cancer has an excellent prognosis after complete surgical resection, disease recurrence still occurs. This study aimed to assess prognostic risk factors in this early stage of disease.

methodsAll non-neoadjuvantly treated stage I colon (CC) and rectal (RC) patients who underwent a surgical resection between 2004 and 2015 were identified. Clinicopathological differences and long-term oncological outcomes were compared.

resultsCC patients (n = 433) were older and had more pre-existing comorbidities. RC patients (n = 86) were associated with more T2 tumors, venous invasion, and higher rates of 30-day morbidity. In multivariate analysis, lymphatic invasion was found to be an independent predictor for disease recurrence (OR 4.57, P = 0.010) and worse disease-free survival (HR 4.26, P = 0.012). This was particularly true for distant recurrence, with eight times higher hazard ratios when lymphatic invasion was present (HR 8.02, P < 0.001). T2 tumors were at risk, though no significant association was found (OR 3.86, P = 0.051; HR 3.61, P = 0.065, respectively).

conclusionsLymphatic invasion was strongly associated with worse DFS, in particular distant recurrence. This subgroup of stage I patients might benefit from a more intensive follow-up and maybe should be considered for adjuvant therapy.

Indexed as

AgedColectomyColorectal NeoplasmsDisease-Free SurvivalFemaleHumansIncidenceLymphatic MetastasisLymph NodesMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPostoperative PeriodPrognosisRetrospective StudiesColorectal cancerDisease recurrenceEarly stagePostoperative morbidityRisk factors

Identifiers

PMID30511134

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.