Evidence map›Paper›PMID 30511125›Full record

ArticleJournal of autism and developmental disorders2019

Decreased Cortical Thickness in the Anterior Cingulate Cortex in Adults with Autism.

Charles Laidi, Jennifer Boisgontier, Amicie de Pierrefeu, Edouard Duchesnay, Sevan Hotier, Marc-Antoine d'Albis, Richard Delorme, Federico Bolognani, Christian Czech, Céline Bouquet and 10 more

Abstract read
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In one paragraph

Article in Journal of autism and developmental disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
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  3. Cortical Thickness and Curvature in Autism and ADHD: A Mega-Analysis.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 7 institutions in 2 countries.

Charles LaidiInstitut National de la Santé et de la Recherche Médicale (INSERM), U955, Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle (Créteil, France), 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France. charleslaidi@gmail.com.ORCID http://orcid.org/0000-0002-2187-6138
Jennifer BoisgontierInstitut National de la Santé et de la Recherche Médicale (INSERM), U955, Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle (Créteil, France), 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.
Amicie de PierrefeuNeuroSpin, CEA, Université Paris-Saclay, Paris, France.
Edouard DuchesnayNeuroSpin, CEA, Université Paris-Saclay, Paris, France.
Sevan HotierInstitut National de la Santé et de la Recherche Médicale (INSERM), U955, Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle (Créteil, France), 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.
Marc-Antoine d'AlbisInstitut National de la Santé et de la Recherche Médicale (INSERM), U955, Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle (Créteil, France), 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.
Richard DelormeCentre expert (Asperger), Fondation Fondamental, Créteil, France.
Federico BolognaniNeuroscience, Ophthalmology, and Rare Diseases (NORD), Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland.
Christian CzechNeuroscience, Ophthalmology, and Rare Diseases (NORD), Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland.
Céline BouquetNeuroscience, Ophthalmology, and Rare Diseases (NORD), Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland.
Anouck AmestoyCharles Perrens Hospital, Autism Expert Center, 121 rue de la Bechade, Bordeaux, France.
Julie PetitService de psychiatrie de l'enfant et de l'adolescent, Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Robert Debré, 48 boulevard Sérurier, 75019, Paris, France.
Štefan HoligaNeuroscience, Ophthalmology, and Rare Diseases (NORD), Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland.
Juergen DukartNeuroscience, Ophthalmology, and Rare Diseases (NORD), Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland.
Alexandru GamanInstitut National de la Santé et de la Recherche Médicale (INSERM), U955, Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle (Créteil, France), 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.
Elie ToledanoInstitut Roche, 30 cours de l'Ile Seguin, 92650, Boulogne-Billancourt cedex, France.
Myriam Ly-Le MoalInstitut Roche, 30 cours de l'Ile Seguin, 92650, Boulogne-Billancourt cedex, France.
Isabelle ScheidInstitut National de la Santé et de la Recherche Médicale (INSERM), U955, Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle (Créteil, France), 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.
Marion LeboyerInstitut National de la Santé et de la Recherche Médicale (INSERM), U955, Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle (Créteil, France), 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.
Josselin HouenouInstitut National de la Santé et de la Recherche Médicale (INSERM), U955, Institut Mondor de Recherche Biomédicale, Psychiatrie Translationnelle (Créteil, France), 51 Avenue du Maréchal de Lattre de Tassigny, 94010, Créteil, France.
Inserm · FRRoche (Switzerland) · CHCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRRoche (France) · FRAssistance Publique – Hôpitaux de Paris · FRCentre Hospitalier Charles Perrens · FRInstitut Pasteur · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is a developmental disorder underdiagnosed in adults. To date, no consistent evidence of alterations in brain structure has been reported in adults with ASD and few studies were conducted at that age. We analyzed structural magnetic resonance imaging data from 167 high functioning adults with ASD and 195 controls. We ran our analyses on a discovery (n = 301) and a replication sample (n = 61). The right caudal anterior cingulate cortical thickness was significantly thinner in adults with ASD compared to controls in both the discovery and the replication sample. Our work underlines the relevance of studying the brain anatomy of an adult ASD population.

Indexed as

AdolescentAdultAutistic DisorderCase-Control StudiesCerebral CortexFemaleHumansMagnetic Resonance ImagingMaleAdultsAnterior cingulate cortexAutismMRI

Identifiers

PMID30511125
OpenAlexW2902423416

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.