ArticleBrain imaging and behavior2020
Modifying the minimum criteria for diagnosing amnestic MCI to improve prediction of brain atrophy and progression to Alzheimer's disease.
Article in Brain imaging and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Hemispheric imbalance in mild cognitive impairment: a graph-theoretical analysis of multimodal brain networks.Annals of medicine · 2026Article
- The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion-Tensor-Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review.Journal of magnetic resonance imaging : JMRI · 2026Review
- Article
- Temporal Muscle Thickness as a New Biomarker: Its Association With Alzheimer Pathology and Cognitive Impairment in Chinese Adults.Journal of cachexia, sarcopenia and muscle · 2025Article
- Comparing the predictive validity of four MCI definitions for incident dementia in demographically diverse community-dwelling individuals: Results from the Einstein Aging Study (EAS).Journal of the International Neuropsychological Society : JINS · 2025Article
- Temporo-frontoparietal hypoconnectivity as a biomarker for isolated language impairment in mild cognitive impairment: A cross-cohort comparison.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Observational
- Cognitive practice effects delay diagnosis of MCI: Implications for clinical trials.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Clinical Utility of Cerebrospinal Fluid Aβ42 and Tau Measures in Diagnosing Mild Cognitive Impairment in Early Onset Dementia.Journal of Alzheimer's disease : JAD · 2022Article
- Novel characterization of the relationship between verbal list-learning outcomes and hippocampal subfields in healthy adults.Human brain mapping · 2021Article
- Article
- Effects of APOE ε2 on the Fractional Amplitude of Low-Frequency Fluctuation in Mild Cognitive Impairment: A Study Based on the Resting-State Functional MRI.Frontiers in aging neuroscience · 2021Article
- Neuroimage Biomarker Identification of the Conversion of Mild Cognitive Impairment to Alzheimer's Disease.Frontiers in neuroscience · 2021Article
- Cognitive Practice Effects Delay Diagnosis; Implications for Clinical Trials.medRxiv : the preprint server for health sciences · 2020Article
- Degree of cognitive impairment does not signify early versus late mild cognitive impairment: confirmation based on Alzheimer's disease polygenic risk.Neurobiology of aging · 2020Article
- Obesity in Late-Life as a Protective Factor Against Dementia and Dementia-Related Mortality.American journal of Alzheimer's disease and other dementiasArticle
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6 authors.
Funding
Abstract
Mild cognitive impairment (MCI) is a heterogeneous condition with variable outcomes. Improving diagnosis to increase the likelihood that MCI reliably reflects prodromal Alzheimer's Disease (AD) would be of great benefit for clinical practice and intervention trials. In 230 cognitively normal (CN) and 394 MCI individuals from the Alzheimer's Disease Neuroimaging Initiative, we studied whether an MCI diagnostic requirement of impairment on at least two episodic memory tests improves 3-year prediction of medial temporal lobe atrophy and progression to AD. Based on external age-adjusted norms for delayed free recall on the Rey Auditory Verbal Learning Test (AVLT), MCI participants were further classified as having normal (AVLT+, above -1 SD, n = 121) or impaired (AVLT -, -1 SD or below, n = 273) AVLT performance. CN, AVLT+, and AVLT- groups differed significantly on baseline brain (hippocampus, entorhinal cortex) and cerebrospinal fluid (amyloid, tau, p-tau) biomarkers, with the AVLT- group being most abnormal. The AVLT- group had significantly more medial temporal atrophy and a substantially higher AD progression rate than the AVLT+ group (51% vs. 16%, p < 0.001). The AVLT+ group had similar medial temporal trajectories compared to CN individuals. Results were similar even when restricted to individuals with above average (based on the CN group mean) baseline medial temporal volume/thickness. Requiring impairment on at least two memory tests for MCI diagnosis can markedly improve prediction of medial temporal atrophy and conversion to AD, even in the absence of baseline medial temporal atrophy. This modification constitutes a practical and cost-effective approach for clinical and research settings.
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