ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2018
Do 2-year changes in superior frontal gyrus and global brain atrophy affect cognition?
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- CSF microtubule-associated protein 1 light chain 3A and 3B levels are associated with tau pathology and Alzheimer's disease risk through amyloid deposition and microglial signaling.Journal of neuroinflammation · 2026Article
- Domain-specific changes in everyday cognition: Associations with diagnosis change and gray matter volume change.Neuropsychology · 2026Article
- The association between gut microbiota and functional connectivity in cognitive impairment of first-episode major depressive disorder.Translational psychiatry · 2025Article
- Atypical Alzheimer's disease: new insights into an overlapping spectrum between the language and visual variants.Journal of neurology · 2024Article
- Introducing ADNP and SIRT1 as new partners regulating microtubules and histone methylation.Molecular psychiatry · 2021Article
- Alzheimer's Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation.Cell reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
introductionMetabolic alterations to the superior frontal gyrus (SFG) have been linked to cognitive decline. Whether these indicate structural atrophy, which could be screened for at a larger scale using noninvasive structural imaging, is unknown.
methodsWe assessed annual structural magnetic resonance imaging scans and cognitive data from 3 consecutive years from 204 participants from the AD Neuroimaging Initiative database (mean age 72.24 [8.175] years). We evaluated associations between brain structural changes and performance in the Montreal Cognitive Assessment, Everyday Cognition Visuospatial subtest (ECog Visuospatial), and Functional Assessment Questionnaire.
resultsChanges in the surface area of the SFG were associated with changes in the outcome of the ECog Visuospatial test ( DISCUSSION: The extent into which (and if) changes in the SFG influence cognition warrant further evaluation in a larger period in more heterogeneous population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.