Evidence map›Paper›PMID 30510968›Full record

ReviewJournal of immunology research2018

Novel Immunotherapeutic Approaches for Neuroblastoma and Malignant Melanoma.

Fabio Morandi, Francesco Frassoni, Mirco Ponzoni, Chiara Brignole

Abstract readReview
In one paragraph

Review in Journal of immunology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. miR-15a and miR-15b modulate natural killer and CD8Molecular therapy oncolytics · 2022
    Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fabio MorandiStem Cell Laboratory and Cell Therapy Center, IRCCS Istituto Giannina Gaslini, 16148 Genova, Italy.ORCID 0000-0002-2849-7595
Francesco FrassoniStem Cell Laboratory and Cell Therapy Center, IRCCS Istituto Giannina Gaslini, 16148 Genova, Italy.
Mirco PonzoniLaboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, 16148 Genova, Italy.
Chiara BrignoleLaboratory of Experimental Therapies in Oncology, IRCCS Istituto Giannina Gaslini, 16148 Genova, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroblastoma (NB) and malignant melanoma (MM), tumors of pediatric age and adulthood, respectively, share a common origin, both of them deriving from the neural crest cells. Although NB and MM have a different behavior, in respect to age of onset, primary tissue involvement and metastatic spread, the prognosis for high stage-affected patients is still poor, in spite of aggressive treatment strategies and the huge amount of new discovered biological knowledge. For these reasons researchers are continuously attempting to find out new treatment options, which in a near future could be translated to the clinical practice. In the last two decades, a strong effort has been spent in the field of translational research of immunotherapy which led to satisfactory results. Indeed, several immunotherapeutic clinical trials have been performed and some of them also resulted beneficial. Here, we summarize preclinical studies based on immunotherapeutic approaches applied in models of both NB and MM.

Indexed as

AdultAnimalsAntineoplastic Combined Chemotherapy ProtocolsChildClinical Trials as TopicDisease Models, AnimalDrug Evaluation, PreclinicalHumansImmunotherapyMelanomaNeural CrestNeuroblastomaRemission InductionTranslational Research, Biomedical

Identifiers

PMID30510968
PMCPMC6232800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.