ArticleTranslational vision science & technology2018
Effects of Age, Race, and Ethnicity on the Optic Nerve and Peripapillary Region Using Spectral-Domain OCT 3D Volume Scans.
Article in Translational vision science & technology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Unsupervised Classification of Wide-Field Swept-Source Optical Coherence Tomography Reveals Patterns Associated With Glaucoma Severity and Progression.Translational vision science & technology · 2026Article
- Red-green disease: overreliance on color-coded OCT RNFL analysis in glaucoma diagnosis.Eye (London, England) · 2026Article
- Smaller Optic Discs Show Higher Macular Flow Density: An Optical Coherence Tomography Angiography Study.Biomedicines · 2026Article
- Magnetic resonance imaging morphological features of the cisternal segment of the trigeminal nerve in Fabry disease.Neuroradiology · 2026Article
- Establishment of Normative Retinal Nerve Fiber Layer Thickness in Healthy Koreans Using Huvitz Optical Coherence Tomography and Comparison with Cirrus OCT.Journal of clinical medicine · 2025Article
- Spectralis Optical Coherence Tomography for Evaluating Ocular Hypertensive and Glaucoma Suspect Eyes: Real-World Data from Taiwan.Diagnostics (Basel, Switzerland) · 2025Article
- Assessment of demographic bias in retinal age prediction machine learning models.Frontiers in artificial intelligence · 2025Article
- Age prediction using fundus parameters of normal eyes from the Kumejima population study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Frequency of Agreement Between Structural and Functional Glaucoma Testing: A Longitudinal Study of 3D OCT and Current Clinical Tests.American journal of ophthalmology · 2024Article
- Individual Prognostication of Disease Activity and Disability Worsening in Multiple Sclerosis With Retinal Layer ThicknessNeurology(R) neuroimmunology & neuroinflammation · 2024Article
- Long-term variability of retinal nerve fibre layer thickness measurement in patients with glaucoma of African and European descents.The British journal of ophthalmology · 2024Article
- Exploring ethnic and racial differences in intraocular pressure and glaucoma: The Canadian Longitudinal Study on aging.Heliyon · 2024Article
- Clinical Factors Associated With Long-Term OCT Variability in Glaucoma.American journal of ophthalmology · 2023Article
- Going beyond the means: Exploring the role of bias from digital determinants of health in technologies.PLOS digital health · 2023Review
- The Relationship Between Fetal Growth and Retinal Nerve Fiber Layer Thickness in a Cohort of Young Adults.Translational vision science & technology · 2022Article
- Preoperative Peripapillary Retinal Nerve Fiber Layer Thickness as the Prognostic Factor of Postoperative Visual Functions After Endoscopic Transsphenoidal Surgery for Pituitary Adenoma.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Hemiretinal Asymmetry in Peripapillary Vessel Density in Healthy, Glaucoma Suspect, and Glaucoma Eyes.American journal of ophthalmology · 2021Article
- Comparing the results of manual and automated quantitative corneal neuroanalysing modules for beginners.Scientific reports · 2021Article
- Structure-Function Mapping Using a Three-Dimensional Neuroretinal Rim Parameter Derived From Spectral Domain Optical Coherence Tomography Volume Scans.Translational vision science & technology · 2021Article
- Birth Weight Is a Significant Predictor of Retinal Nerve Fiber Layer Thickness at 36 Weeks Postmenstrual Age in Preterm Infants.American journal of ophthalmology · 2021Observational
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 6 countries.
Funding
Abstract
purposeTo evaluate the effects of age, race, and ethnicity on the optic nerve and peripapillary retina using spectral-domain optical coherence tomography (SD-OCT) three-dimensional (3D) volume scans in normal subjects.
methodsThis is a cross-sectional study performed at a single institution in Boston. All patients received retinal nerve fiber layer (RNFL) scans and an optic nerve 3D volume scan. The SD-OCT software calculated peripapillary RNFL thickness, retinal thickness (RT), and retinal volume (RV). Custom-designed software calculated neuroretinal rim minimum distance band (MDB) thickness and area.
resultsThere were 272 normal subjects, including 175 whites, 40 blacks, 40 Asians, and 17 Hispanics. Rates of age-related decline were 2.3%, 2.0%, 1.7%, 3.3%, and 4.3% per decade for RNFL, RT, RV, MDB neuroretinal rim thickness, and MDB area, respectively. The RNFL was most affected by racial and ethnic variations, with Asians having thicker global, superior, and inferior RNFL, Hispanics having thicker inferior RNFL, and blacks having thinner temporal RNFL, compared to whites. For MDB thickness and area, Asians had smaller nasal values and blacks had smaller temporal values. Peripapillary RT and RV parameters were not influenced by race and ethnicity.
conclusionsAll of the parameters exhibited age-related declines. RNFL, MDB thickness, and MDB area demonstrated racial and ethnic variations, while peripapillary RT and RV did not. TRANSLATIONAL RELEVANCE: This study demonstrates that both normal aging and ethnicity affect several novel 3D OCT parameters used to diagnose and monitor glaucoma (i.e., RT, RV, and MDB), and this should be factored in when making clinical decisions based on these parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.