ArticleAmerican journal of nuclear medicine and molecular imaging2018
Chemotherapy-induced coronary arteries calcium score deterioration as detected with unenhanced CT portion of FDG PET/CT.
Article in American journal of nuclear medicine and molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- The role of imaging in defining cardiovascular risk to help cancer patient management: a scoping review.Insights into imaging · 2025Review
- Association of Cardiovascular Risk Factors and Coronary Calcium Burden with Epicardial Adipose Tissue Volume Obtained from PET-CT Imaging in Oncological Patients.Journal of cardiovascular development and disease · 2024Article
- Medial Arterial Calcification: A Significant and Independent Contributor of Peripheral Artery Disease.Arteriosclerosis, thrombosis, and vascular biology · 2022Review
- Novel Cardiac Computed Tomography Methods for the Assessment of Anthracycline Induced Cardiotoxicity.Frontiers in cardiovascular medicine · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to detect the potential impact of chemotherapy on the coronary calcium scoring (CCS) in lymphoma patients undergoing FDG-PET/CT at baseline and for therapy response using the CT portion of the exam to calculate the CCS. One hundred twelve lymphoma patients were included in the study based on having both baseline and at least 2 post-chemotherapy scans. The unenhanced CT portions of the scans were reviewed to measure the CCS which was then extracted using the Toshiba Vital Program. Agatston scores were assessed as category 1 with zero CCS unit and categories 2 to 5 having more than >1, 11, 101, and 400 CCS units respectively. For statistical analysis, paired T-Tests were used to compare results. The overall changes in total coronary artery calcium (CAC) from baseline to last treatment showed a statistically significant increase in CAC with an average increase of at least 35% in the CAC score. We also compared the overall changes in CAC with patients having category 1 and 2 Agatston at baseline and found no statistical increase in CAC post-chemotherapy. Additionally, we compared the overall changes in CAC with patients having category 3 and 4 Agatston at baseline and found statistically significant increase in CAC post-chemotherapy. In lymphoma patients, chemotherapy may cause worsening of CCS and this can serve as an early indicator of chemotherapy-induced cardiac toxicity. When present, such CCS deterioration can be detected by the unenhanced CT portion of routine oncologic FDG PET/CT scans.
Indexed as
Identifiers
30510848PMC6261876W2994300286What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.