Evidence map›Paper›PMID 30510769›Full record

ArticleNPJ biofilms and microbiomes2018

Oxidative stress in the oral cavity is driven by individual-specific bacterial communities.

Mária Džunková, Daniel Martinez-Martinez, Roman Gardlík, Michal Behuliak, Katarína Janšáková, Nuria Jiménez, Jorge F Vázquez-Castellanos, Jose Manuel Martí, Giuseppe D'Auria, H M H N Bandara and 3 more

Open access · goldAbstract read
In one paragraph

Article in NPJ biofilms and microbiomes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 36 citations in OpenAlex.

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  9. Saliva assay: a call for methodological standardization.Journal of periodontal & implant science · 2025
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Role of Hydrogen Sulfide in Oral Disease.Oxidative medicine and cellular longevity · 2022
    Review
  16. Article
  17. Effect of cerebral palsy and dental caries on dental plaque index, salivary parameters and oxidative stress in children and adolescents.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2021
    Article
  18. Article
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 5 countries.

Mária Džunková *1Department of Genomics and Health, Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO-Public Health), Valencia, Spain.
Daniel Martinez-Martinez *1Department of Genomics and Health, Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO-Public Health), Valencia, Spain.
Roman Gardlík5Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Michal Behuliak5Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Katarína Janšáková5Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Nuria Jiménez1Department of Genomics and Health, Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO-Public Health), Valencia, Spain.
Jorge F Vázquez-Castellanos1Department of Genomics and Health, Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO-Public Health), Valencia, Spain.
Jose Manuel Martí3Institute for Integrative Systems Biology (I2SysBio), The University of Valencia and The Spanish National Research Council (CSIC)-UVEG, Valencia, Spain.
Giuseppe D'AuriaCIBER in Epidemiology and Public Health (CIBEResp), Madrid, Spain.
H M H N Bandara9School of Dentistry, The University of Queensland, Herston, QLD Australia.
Amparo Latorre1Department of Genomics and Health, Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO-Public Health), Valencia, Spain.
Peter Celec5Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Andrés Moya1Department of Genomics and Health, Foundation for the Promotion of Health and Biomedical Research of Valencia Region (FISABIO-Public Health), Valencia, Spain.ORCID 0000-0002-2867-1119
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · ESComenius University Bratislava · SKThe University of Queensland · AUConsejo Superior de Investigaciones Científicas · ESCzech Academy of Sciences · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The term "bacterial dysbiosis" is being used quite extensively in metagenomic studies, however, the identification of harmful bacteria often fails due to large overlap between the bacterial species found in healthy volunteers and patients. We hypothesized that the pathogenic oral bacteria are individual-specific and they correlate with oxidative stress markers in saliva which reflect the inflammatory processes in the oral cavity. Temporally direct and lagged correlations between the markers and bacterial taxa were computed individually for 26 volunteers who provided saliva samples during one month (21.2 ± 2.7 samples/volunteer, 551 samples in total). The volunteers' microbiomes differed significantly by their composition and also by their degree of microbiome temporal variability and oxidative stress markers fluctuation. The results showed that each of the marker-taxa pairs can have negative correlations in some volunteers while positive in others.

Identifiers

PMID30510769
PMCPMC6258756
OpenAlexW2901029484

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.