Evidence map›Paper›PMID 30510632›Full record

ArticleOxidative medicine and cellular longevity2018

Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation.

I-Cheng Chen, Te-Hsien Lin, Yu-Hsuan Hsieh, Chih-Ying Chao, Yih-Ru Wu, Kuo-Hsuan Chang, Ming-Chung Lee, Guey-Jen Lee-Chen, Chiung-Mei Chen

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

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  11. Glycyrrhizic Acid Alleviates Semen Strychni-Induced Neurotoxicity Through the Inhibition of HMGB1 Phosphorylation and Inflammatory Responses.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

I-Cheng ChenDepartment of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei 10507, Taiwan.ORCID 0000-0001-6235-6289
Te-Hsien LinDepartment of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.ORCID 0000-0002-1107-772X
Yu-Hsuan HsiehDepartment of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.
Chih-Ying ChaoDepartment of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei 10507, Taiwan.
Yih-Ru WuDepartment of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei 10507, Taiwan.ORCID 0000-0003-1191-2542
Kuo-Hsuan ChangDepartment of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei 10507, Taiwan.ORCID 0000-0003-4972-9823
Ming-Chung LeeSun Ten Pharmaceutical Co. Ltd., New Taipei City 23143, Taiwan.
Guey-Jen Lee-ChenDepartment of Life Science, National Taiwan Normal University, Taipei 11677, Taiwan.ORCID 0000-0003-4818-9917
Chiung-Mei ChenDepartment of Neurology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei 10507, Taiwan.ORCID 0000-0002-0769-0353
Chang Gung University · TWNational Taiwan Normal University · TWSun Chemical (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Misfolded tau proteins induce accumulation of free radicals and promote neuroinflammation by activating microglia-releasing proinflammatory cytokines, leading to neuronal cell death. Traditional Chinese herbal medicines (CHMs) have been widely used in clinical practice to treat neurodegenerative diseases associated with oxidative stress and neuroinflammation. This study examined the neuroprotection effects of formulated CHMs Bai-Shao (made of

Indexed as

Drug CompoundingAnimalsAnti-Inflammatory AgentsAntioxidantsApoptosisCells, CulturedDrugs, Chinese HerbalHEK293 CellsHumansInflammationInflammation MediatorsMiceMicrogliaNeuroblastomaNeuronsNeuroprotective AgentsAnti-Inflammatory AgentsAntioxidantsDrugs, Chinese HerbalInflammation MediatorsNeuroprotective Agents

Identifiers

PMID30510632
PMCPMC6230396
OpenAlexW2898165107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.