ArticleFrontiers in psychiatry2018
Prenatal Progestin Exposure Is Associated With Autism Spectrum Disorders.
Article in Frontiers in psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Advancing understanding of the mechanisms of autism spectrum disorder through perinatal risk factors.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Effects of Endocrine-Disrupting Chemicals in the Brain: The Example of Neurodevelopment Alterations upon Exposure In Utero to Synthetic Sex Hormones.Journal of xenobiotics · 2025Review
- Effects of maternal exposure to exogenous progesterone during pregnancy on offspring neurodevelopment.BMC pediatrics · 2025Observational
- Unraveling the Genetic and Environmental Risk Factors of Autism Spectrum Disorder Through a Case-Control Study in Armenia.Health science reports · 2025Article
- Article
- A case-control study on pre-, peri-, and neonatal risk factors associated with autism spectrum disorder among Armenian children.Scientific reports · 2024Article
- Giftedness and atypical sexual differentiation: enhanced perceptual functioning through estrogen deficiency instead of androgen excess.Frontiers in endocrinology · 2024Review
- Chemogenetic rectification of the inhibitory tone onto hippocampal neurons reverts autistic-like traits and normalizes local expression of estrogen receptors in the Ambra1+/- mouse model of female autism.Translational psychiatry · 2023Article
- Effects of prenatal exposure to synthetic sex hormones on neurodevelopment: a biological mechanism.Frontiers in molecular neuroscience · 2023Review
- Editorial: The commonality in converged pathways and mechanisms underpinning neurodevelopmental and psychiatric disorders.Frontiers in molecular neuroscience · 2023Article
- Hematopoietic stem cell transplantation ameliorates maternal diabetes-mediated gastrointestinal symptoms and autism-like behavior in mouse offspring.Annals of the New York Academy of Sciences · 2022Article
- Maternal diabetes-mediated RORA suppression contributes to gastrointestinal symptoms in autism-like mouse offspring.BMC neuroscience · 2022Article
- Maternal diabetes-mediated RORA suppression in mice contributes to autism-like offspring through inhibition of aromatase.Communications biology · 2022Article
- Diethylstilbestrol and autism.Frontiers in endocrinology · 2022Review
- Prenatal Progestin Exposure-Mediated Oxytocin Suppression Contributes to Social Deficits in Mouse Offspring.Frontiers in endocrinology · 2022Article
- Children neuropsychological and behavioral scale-revision 2016 in the early detection of autism spectrum disorder.Frontiers in psychiatry · 2022Article
- Expression and structural analysis of human neuroligin 2 and neuroligin 3 implicated in autism spectrum disorders.Frontiers in endocrinology · 2022Article
- Prenatal Exposure to Diethylstilbestrol and Multigenerational Psychiatric Disorders: An Informative Family.International journal of environmental research and public health · 2021Article
- Prevalence and Developmental Profiles of Autism Spectrum Disorders in Children With Global Developmental Delay.Frontiers in psychiatry · 2021Article
- Hormonal Contraception and Violent Death: The Physiological and Psychological Links.Frontiers in behavioral neuroscience · 2021Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously reported that prenatal progestin exposure induces autism-like behavior in offspring through ERβ (estrogen receptor β) suppression in the brain, indicating that progestin may induce autism spectrum disorders (ASD). In this study, we aim to investigate whether prenatal progestin exposure is associated with ASD. A population-based case-control epidemiology study was conducted in Hainan province of China. The ASD children were first screened with the Autism Behavior Checklist (ABC) questionnaire, and then diagnosed by clinical professionals using the ASD diagnosis criteria found in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V). Eventually, 235 cases were identified as ASD from 37863 children aged 0-6 years old, and 682 matched control subjects with typically developing children were selected for the analysis of potential impact factors on ASD prevalence using multivariate logistic regression. Our data show that the ASD prevalence rate in Hainan was 0.62% with a boy:girl ratio of 5.4:1. Interestingly, we found that the following factors were strongly associated with ASD prevalence: use of progestin to prevent threatened abortion, use of progestin contraceptives at the time of conception, and prenatal consumption of progestin-contaminated seafood during the first trimester of pregnancy. All the above factors were directly or indirectly involved with prenatal progestin exposure. Additionally, we conducted
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