ArticleInternational journal of nanomedicine2018
Enhancement of wound healing by single-wall/multi-wall carbon nanotubes complexed with chitosan.
Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- A critical overview of challenging roles of medicinal plants in improvement of wound healing technology.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Pooled it
- Aloe vera integrated ZnO/SWCNT/Ag nanocomposites for accelerated wound repair and scar reduction.Journal of materials science. Materials in medicine · 2026Article
- Antimicrobial Strategies for Chronic Cutaneous Ulcers: From Preclinical Nanotechnology to Clinical Practice.International journal of nanomedicine · 2026Review
- Carbon nanomaterials: Exploring new frontiers in wound healing therapy.Bioengineering & translational medicine · 2025Review
- Multifunctional Carbon-Based Nanocomposite Hydrogels for Wound Healing and Health Management.Gels (Basel, Switzerland) · 2025Review
- Nanomedicine and Its Role in Surgical Wound Infections: A Practical Approach.Bioengineering (Basel, Switzerland) · 2025Review
- Nanomaterials in the Wound Healing Process: New Insights and Advancements.Pharmaceutics · 2024Review
- Precise healing of oral and maxillofacial wounds: tissue engineering strategies and their associated mechanisms.Frontiers in bioengineering and biotechnology · 2024Review
- Cell Therapy and Investigation of the Angiogenesis of Fibroblasts with Collagen Hydrogel on the Healing of Diabetic Wounds.Turkish journal of pharmaceutical sciences · 2023Article
- Local Drug Delivery Strategies towards Wound Healing.Pharmaceutics · 2023Review
- Noncovalent functionalization of carbon nanotubes as a scaffold for tissue engineering.Scientific reports · 2022Article
- Review
- Biocompatible and Antimicrobial Cellulose Acetate-Collagen Films Containing MWCNTs Decorated with TiONanomaterials (Basel, Switzerland) · 2022Article
- State of the Art in the Antibacterial and Antiviral Applications of Carbon-Based Polymeric Nanocomposites.International journal of molecular sciences · 2021Review
- Nanomaterials in Wound Healing and Infection Control.Antibiotics (Basel, Switzerland) · 2021Review
- Modulating the Biomechanical Properties of Engineered Connective Tissues by Chitosan-Coated Multiwall Carbon Nanotubes.International journal of nanomedicine · 2021Article
- Integration of microbubbles with biomaterials in tissue engineering for pharmaceutical purposes.Heliyon · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundImpaired wound healing is commonly associated with many health problems, including diabetes, bedsores and extensive burns. In such cases, healing often takes a long time, which subjects patients to various complications. This study aims to investigate whether single-wall or multi-wall carbon nanotubes complexed with chitosan hydrogel can improve wound healing. MATERIALS AND
methodsInitially, the effects of the complexes on the viability and functionality of fibroblasts were investigated in engineered connective tissues. Then, their activity on wound healing was investigated in a mouse model with induced full-thickness wounds, in which the wounds were treated daily with these complexes. Finally, the effect of the complexes on collagen deposition by fibroblasts was investigated in vitro.
resultsThe engineered connective tissue studies showed that fibroblasts were viable in the presence of the complexes and were still able to effectively organize and contract the extracellular matrix. In vivo data showed that both types of complexes improved the re-epithelialization of the healing wounds; however, they also increased the percentage of wounds with higher fibrosis. In particular, the chitosan-multi-wall carbon nanotube complex significantly enhanced the extensiveness of this fibrosis, which is in line with in vitro data showing a concentration-dependent enhancement of collage deposition by these complexes. These observations were associated with an increase in inflammatory signs in the wound bed.
conclusionSingle-wall and multi-wall carbon nanotubes complexed with chitosan improved the re-epithelialization of wounds, but an increase in fibrosis was detected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.