Evidence map›Paper›PMID 30510397›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2018

Peripapillary microvasculature in the retinal nerve fiber layer in glaucoma by optical coherence tomography angiography: focal structural and functional correlations and diagnostic performance.

Grace M Richter, Beau Sylvester, Zhongdi Chu, Bruce Burkemper, Ingy Madi, Ryuna Chang, Alena Reznik, Rohit Varma, Ruikang K Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 48 citations in OpenAlex.

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  17. Optical Coherence Tomography for Ophthalmology Imaging.Advances in experimental medicine and biology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Grace M RichterDepartment of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA, grace.richter@med.usc.edu.
Beau SylvesterDepartment of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA, grace.richter@med.usc.edu.
Zhongdi ChuDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
Bruce BurkemperDepartment of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA, grace.richter@med.usc.edu.
Ingy MadiDepartment of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA, grace.richter@med.usc.edu.
Ryuna ChangDepartment of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA, grace.richter@med.usc.edu.
Alena ReznikDepartment of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA, grace.richter@med.usc.edu.
Rohit VarmaDepartment of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA, grace.richter@med.usc.edu.
Ruikang K WangDepartment of Bioengineering, University of Washington, Seattle, WA, USA.
University of Southern California · USUniversity of Washington · US

Funding

NON-INVASIVE REAL-TIME LABEL-FREE 3D IMAGING OF RETINAL MICROCIRCULATIONR01EY024158 · NEI · UNIVERSITY OF WASHINGTON · PI WANG, RUIKANG · 2014 to 2017
$1.7M
Defining the Relationships of Retinal Microcirculation with Glaucoma, Systemic Disease, and Ocular Anatomic Factors in African AmericansK23EY027855 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RICHTER, GRACE MARIE · 2017 to 2021
$984k
Functional Imaging in Hypoxic-Ischemic Retinal DiseaseK08EY027006 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KASHANI, AMIR H · 2016 to 2020
$978k
NEI NIH HHS K08 EY027006NEI NIH HHS K23 EY027855NEI NIH HHS R01 EY024158
6 · The paper itself

Abstract

purposeTo quantify peripapillary microvasculature within the retinal nerve fiber layer (RNFL) in primary open-angle glaucoma (POAG) and normal eyes, determine association of perfusion parameters with structural and functional measures, and report diagnostic accuracy of perfusion parameters. PATIENTS AND

methodsPOAG and normal patients underwent 6×6 mm

resultsThirty-eight POAG and 17 normal eyes were studied. Global VAD, VSD, and VCI were reduced in mild POAG vs normal (

conclusionGlaucomatous eyes showed stepwise reductions in RNFL microcirculation across severity; focal reductions in the inferior hemisphere and inferior and superior quadrants were most significant. OCTA parameters had stronger associations with structural rather than functional measures of glaucoma.

Indexed as

diagnostic accuracyfunctionlarge vessel subtractionmicro-circulationoptic nerve headsegmentationstructure

Identifiers

PMID30510397
PMCPMC6231432
OpenAlexW2900253472

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.