Evidence map›Paper›PMID 30510376›Full record

ArticleWorld journal of gastroenterology2018

Involvement of methylation-associated silencing of formin 2 in colorectal carcinogenesis.

Dao-Jiang Li, Zhi-Cai Feng, Xiao-Rong Li, Gui Hu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dao-Jiang LiDepartment of Gastrointestinal Surgery, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Zhi-Cai FengDepartment of Burns and Plastic Surgery, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Xiao-Rong LiDepartment of Gastrointestinal Surgery, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.
Gui HuDepartment of Gastrointestinal Surgery, the Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China. xy3zzz@csu.edu.cn.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate whether promoter methylation is responsible for the silencing of formin 2 (

methodsWe first identified the expression levels and methylation levels of

resultsA statistically significant downregulation of

conclusionFMN2 promoter hypermethylation may be an important early event in CRC, most likely playing a critical role in cancer initiation, and can serve as an ideal diagnostic biomarker in elderly patients with early-stage colon cancer.

Indexed as

AgedAge FactorsBiomarkers, TumorCarcinogenesisCell Line, TumorColorectal NeoplasmsDatasets as TopicDecitabineDNA MethylationDown-RegulationFemaleForminsGene Expression Regulation, NeoplasticGene SilencingHumansMaleBiomarkers, TumorDecitabineFmn2 protein, humanForminsMicrofilament ProteinsNuclear ProteinsColorectal cancerEarly-stage cancerFormin 2MethylationMethylation-associated silencing

Identifiers

PMID30510376
PMCPMC6262250
OpenAlexW2903129741

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.