ArticleNature nanotechnology2019
Nanoscale tweezers for single-cell biopsies.
Article in Nature nanotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 184 citations in OpenAlex.
- Perspective on Scanning Electrochemical Probe Microscopy in Single-Cell Imaging.Chemical & biomedical imaging · 2026Review
- Engineering a Biological Nanopore for Monitoring Protein Dynamics and Conformational Changes at the Single-Molecule Level.ACS nano · 2026Article
- Dielectrophoretic and acoustophoretic dual-sensing electroluminescent display.Nature communications · 2026Article
- Tracking Gene Expression of Single Mitochondria in Live Neurons Using Nanotweezers.Journal of the American Chemical Society · 2026Article
- Freeform optical flow based on meta-conveyors for compact, programmable in situ nanomanipulation.Nature communications · 2026Article
- A Nanotube Injector for Cytoplasmic Transfer and Enhanced Mitochondrial Function.Small science · 2026Article
- Programmable electric tweezers.Science advances · 2026Article
- Label-free robotic mitochondrial biopsy.Science advances · 2025Article
- Spatial and Temporal Single-Cell Profiling of RNA Compartmentalization in Neurons with Nanotweezers.ACS nano · 2025Article
- Nanopore approaches for single-molecule temporal omics: promises and challenges.Nature methods · 2025Review
- Exploring the Frontiers of Cell Temperature Measurement and Thermogenesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Nanobiopsy investigation of the subcellular mtDNA heteroplasmy in human tissues.Scientific reports · 2024Article
- Single-cell nanobiopsy enables multigenerational longitudinal transcriptomics of cancer cells.Science advances · 2024Article
- Microtubule-Mediated Regulation of βCirculation research · 2023Article
- Fabrication of electron tunneling probes for measuring single-protein conductance.Nature protocols · 2023Review
- Recent advances in single-cell subcellular sampling.Chemical communications (Cambridge, England) · 2023Review
- Advances in single-molecule junctions as tools for chemical and biochemical analysis.Nature chemistry · 2023Review
- Electromagnetic Forces and Torques: From Dielectrophoresis to Optical Tweezers.Chemical reviews · 2023Review
- Functional nucleic acid engineered double-barreled nanopores for measuring sodium to potassium ratio at single-cell level.Exploration (Beijing, China) · 2022Article
- A subcellular cookie cutter for spatial genomics in human tissue.Analytical and bioanalytical chemistry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Much of the functionality of multicellular systems arises from the spatial organization and dynamic behaviours within and between cells. Current single-cell genomic methods only provide a transcriptional 'snapshot' of individual cells. The real-time analysis and perturbation of living cells would generate a step change in single-cell analysis. Here we describe minimally invasive nanotweezers that can be spatially controlled to extract samples from living cells with single-molecule precision. They consist of two closely spaced electrodes with gaps as small as 10-20 nm, which can be used for the dielectrophoretic trapping of DNA and proteins. Aside from trapping single molecules, we also extract nucleic acids for gene expression analysis from living cells without affecting their viability. Finally, we report on the trapping and extraction of a single mitochondrion. This work bridges the gap between single-molecule/organelle manipulation and cell biology and can ultimately enable a better understanding of living cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.