ArticleNature communications2018
Honey bee Royalactin unlocks conserved pluripotency pathway in mammals.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Ectopic expression of structurally similar major royal jelly proteins reveals their distinct functions inJournal of Zhejiang University. Science. B · 2026Article
- Synergistic Therapeutic Effects of Chitosan and Royal Jelly.Polymers · 2025Review
- Pharmaceutical and Therapeutic Applications of Royal Jelly for Ocular Surface Diseases: A Comprehensive Review.Journal of ophthalmic & vision research · 2025Review
- Royal Jelly: Biological Action and Health Benefits.International journal of molecular sciences · 2024Review
- Royal Jelly Enhances the Ability of Myoblast C2C12 Cells to Differentiate into Multilineage Cells.Molecules (Basel, Switzerland) · 2024Article
- Effects of royal jelly on the antisenescence, mitochondrial viability and osteogenic differentiation capacity of umbilical cord-derived mesenchymal stem cells.Histochemistry and cell biology · 2024Article
- Diverse Regulatory Manners and Potential Roles of lncRNAs in the Developmental Process of Asian Honey Bee (International journal of molecular sciences · 2023Article
- Royal jelly extracellular vesicles promote wound healing by modulating underlying cellular responses.Molecular therapy. Nucleic acids · 2023Article
- Article
- Royal Jelly Increases Hematopoietic Stem Cells in Peripheral Blood: A Double-Blind, Placebo-Controlled, Randomized Trial in Healthy Subjects.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Bioactives from Bee Products and Accompanying Extracellular Vesicles as Novel Bioactive Components for Wound Healing.Molecules (Basel, Switzerland) · 2021Review
- A cross-species analysis of systemic mediators of repair and complex tissue regeneration.NPJ Regenerative medicine · 2021Review
- Review
- Theoretical Analysis of S, M and N Structural Proteins by the Protein-RNA Recognition Code Leads to Genes/proteins that Are Relevant to the SARS-CoV-2 Life Cycle and Pathogenesis.Frontiers in genetics · 2021Article
- Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans.International journal of molecular sciences · 2019Review
- The rise and fall of major royal jelly proteins during a honeybee (Ecology and evolution · 2019Article
- A distal enhancer maintaining Hoxa1 expression orchestrates retinoic acid-induced early ESCs differentiation.Nucleic acids research · 2019Article
Corrections and comments
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Authors and funding
29 authors.
Funding
Abstract
Royal jelly is the queen-maker for the honey bee Apis mellifera, and has cross-species effects on longevity, fertility, and regeneration in mammals. Despite this knowledge, how royal jelly or its components exert their myriad effects has remained poorly understood. Using mouse embryonic stem cells as a platform, here we report that through its major protein component Royalactin, royal jelly can maintain pluripotency by activating a ground-state pluripotency-like gene network. We further identify Regina, a mammalian structural analog of Royalactin that also induces a naive-like state in mouse embryonic stem cells. This reveals an important innate program for stem cell self-renewal with broad implications in understanding the molecular regulation of stem cell fate across species.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.