Evidence map›Paper›PMID 30510241›Full record

SynthesisNature genetics2019

Discovery of common and rare genetic risk variants for colorectal cancer.

Jeroen R Huyghe, Stephanie A Bien, Tabitha A Harrison, Hyun Min Kang, Sai Chen, Stephanie L Schmit, David V Conti, Conghui Qu, Jihyoun Jeon, Christopher K Edlund and 189 more

Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 357 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
357citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02328677 recruitingnot on this map

ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis

TypeobservationalSponsorUniversity of UtahRan2007 to 2030Enrolled5,000ConditionsColorectal Cancer
3 · Its place in the literature

Who cites it

357 citing papers in PubMed, 14 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Genome-wide association studies and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2024
    Pooled it
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  8. Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023
    Pooled it
  9. Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Guideline
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  15. Review
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  19. Review
  20. Article

297 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

199 authors.

Jeroen R Huyghe *Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-6027-9806
Stephanie A Bien *Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Tabitha A Harrison *Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-4173-7530
Hyun Min KangDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Sai ChenDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-3106-5643
Stephanie L SchmitDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.ORCID http://orcid.org/0000-0001-5931-1194
David V ContiDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Conghui QuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jihyoun JeonDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7003-3412
Christopher K EdlundDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Peyton GreensideBiomedical Informatics Program, Stanford University, Stanford, CA, USA.
Michael WainbergDepartment of Computer Science, Stanford University, Stanford, CA, USA.
Fredrick R SchumacherDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA.ORCID http://orcid.org/0000-0002-3073-7463
Joshua D SmithDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
David M LevineDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Sarah C NelsonDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2109-6465
Nasa A Sinnott-ArmstrongDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-4490-0601
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
M Henar AlonsoCancer Prevention and Control Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.ORCID http://orcid.org/0000-0003-0285-5451
Kristin AndersonDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Coral Arnau-CollellGastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0001-9320-8684
Christina BamiaHellenic Health Foundation, Athens, Greece.
Barbara L BanburyPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
John A BaronDepartment of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Stéphane BézieauService de Génétique Médicale, Centre Hospitalier Universitaire (CHU) Nantes, Nantes, France.ORCID http://orcid.org/0000-0003-0095-1319
D Timothy BishopLeeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0002-8752-8785
Juergen BoehmHuntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.
Heiner BoeingDepartment of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbrücke, Germany.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Stefanie BrezinaInstitute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0001-5238-6900
Stephan BuchDepartment of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany.
Daniel D BuchananColorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0003-2225-6675
Andrea Burnett-HartmanInstitute for Health Research, Kaiser Permanente Colorado, Denver, CO, USA.
Katja ButterbachDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Bette J CaanDivision of Research, Kaiser Permanente Medical Care Program, Oakland, CA, USA.
Peter T CampbellBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.
Christopher S CarlsonPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Sergi Castellví-BelGastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-2324-3393
Maria-Dolores ChirlaqueCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Sang Hee ChoDepartment of Hematology-Oncology, Chonnam National University Hospital, Hwasun, South Korea.
Charles M ConnollyPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Amanda J CrossDepartment of Epidemiology and Biostatistics, Imperial College London, London, UK.
Katarina CukDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Keith R CurtisPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Albert de la ChapelleDepartment of Cancer Biology and Genetics and the Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-9345-9248
Kimberly F DohenyCenter for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
David DugganTranslational Genomics Research Institute - An Affiliate of City of Hope, Phoenix, AZ, USA.
Douglas F EastonDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2444-3247
Sjoerd G EliasJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Faye ElliottLeeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK.
Dallas R EnglishCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Edith J M FeskensDivision of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands.
Jane C FigueiredoDepartment of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Rocky FischerUniversity of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA.
Liesel M FitzGeraldCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
David FormanInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Manish GalaDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Steven GallingerLunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
W James GaudermanDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Graham G GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Elizabeth GillandersDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.
Jian GongPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Phyllis J GoodmanSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
William M GradyClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
John S GroveUniversity of Hawaii Cancer Research Center, Honolulu, HI, USA.
Andrea GsurInstitute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Marc J GunterNutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Robert W HaileDivision of Oncology, Department of Medicine, Stanford University, Stanford, CA, USA.
Jochen HampeDepartment of Medicine I, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany.ORCID http://orcid.org/0000-0002-2421-6127
Heather HampelDivision of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Sophia HarlidDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
Richard B HayesDivision of Epidemiology, Department of Population Health, New York University School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-0918-661X
Philipp HoferInstitute of Cancer Research, Department of Medicine I, Medical University of Vienna, Vienna, Austria.ORCID http://orcid.org/0000-0003-2550-6019
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Wan-Ling HsuDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Wen-Yi HuangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-4440-3368
Thomas J HudsonOntario Institute for Cancer Research, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0002-1376-4849
David J HunterDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
Gemma Ibañez-SanzCancer Prevention and Control Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.
Gregory E IdosDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Roxann IngersollCenter for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
Rebecca D JacksonDepartment of Medicine, Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, OH, USA.
Eric J JacobsBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-8458-7659
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-8964-6160
Amit D JoshiClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-7581-6934
Corinne E JoshuDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Temitope O KekuCenter for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA.
Timothy J KeyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Hyeong Rok KimDepartment of Surgery, Chonnam National University Hwasun Hospital and Medical School, Hwasun, Korea.
Emiko KobayashiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Laurence N KolonelOffice of Public Health Studies, University of Hawaii Manoa, Honolulu, HI, USA.
Charles KooperbergPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Tilman KühnDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Sébastien KüryService de Génétique Médicale, Centre Hospitalier Universitaire (CHU) Nantes, Nantes, France.ORCID http://orcid.org/0000-0001-5497-0465
Sun-Seog KweonDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.
Susanna C LarssonInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-0118-0341
Cecelia A LaurieDepartment of Biostatistics, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-6569-2501
Loic Le MarchandUniversity of Hawaii Cancer Research Center, Honolulu, HI, USA.
Suzanne M LealCenter for Statistical Genetics, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Soo Chin LeeDepartment of Haematology-Oncology, National University Cancer Institute, Singapore, Singapore.
Flavio LejbkowiczThe Clalit Health Services, Personalized Genomic Service, Carmel, Haifa, Israel.
Mathieu LemireOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Christopher I LiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Li LiCenter for Community Health Integration and Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA.
Wolfgang LiebInstitute of Epidemiology, PopGen Biobank, Christian-Albrechts-University Kiel, Kiel, Germany.
Yi LinPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Annika LindblomDepartment of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
Noralane M LindorDepartment of Health Science Research, Mayo Clinic, Scottsdale, AZ, USA.
Hua LingCenter for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
Tin L LouieDepartment of Biostatistics, University of Washington, Seattle, WA, USA.
Satu MännistöDepartment of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
Sanford D MarkowitzDepartments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University, and University Hospitals of Cleveland, Cleveland, OH, USA.
Vicente MartínCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.ORCID http://orcid.org/0000-0003-0552-2804
Giovanna MasalaCancer Risk Factors and Life-Style Epidemiology Unit, Institute of Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy.ORCID http://orcid.org/0000-0002-5758-9069
Caroline E McNeilUSC Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.
Marilena MelasDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Roger L MilneCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0001-5764-7268
Lorena MorenoGastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain.
Neil MurphyNutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Robin MyteDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
Alessio NaccaratiDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.ORCID http://orcid.org/0000-0001-5774-0905
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8786-0043
Kenneth OffitClinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Shuji OginoBroad Institute of Harvard and MIT, Cambridge, MA, USA.
N Charlotte Onland-MoretJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Barbara PardiniItalian Institute for Genomic Medicine (IIGM), Turin, Italy.ORCID http://orcid.org/0000-0001-9571-4257
Patrick S ParfreyThe Clinical Epidemiology Unit, Memorial University Medical School, Newfoundland, Canada.
Rachel PearlmanDivision of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA.
Vittorio PerducaLaboratoire de Mathématiques Appliquées MAP5 (UMR CNRS 8145), Université Paris Descartes, Paris, France.ORCID http://orcid.org/0000-0003-0339-0473
Paul D P PharoahDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-8494-732X
Mila PinchevDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.
Elizabeth A PlatzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Ross L PrenticePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Elizabeth PughCenter for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
Leon RaskinDivision of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-1195-7214
Gad RennertDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.ORCID http://orcid.org/0000-0002-8512-068X
Hedy S RennertDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.
Elio RiboliSchool of Public Health, Imperial College London, London, UK.
Miguel Rodríguez-BarrancoCIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Jane RommCenter for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
Lori C SakodaPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Clemens SchafmayerDepartment of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Robert E SchoenDepartment of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Daniela SeminaraDivision of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA.
Mitul ShahCentre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Tameka ShelfordCenter for Inherited Disease Research (CIDR), Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD, USA.
Min-Ho ShinDepartment of Preventive Medicine, Chonnam National University Medical School, Gwangju, Korea.ORCID http://orcid.org/0000-0002-2217-5624
Katerina ShulmanOncology Unit, Hillel Yaffe Medical Center, Hadera, Israel.
Sabina SieriEpidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Martha L SlatteryDepartment of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
Melissa C SoutheyGenetic Epidemiology Laboratory, Department of Pathology, The University of Melbourne, Melbourne, Australia.
Zsofia K StadlerDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Christa StegmaierSaarland Cancer Registry, Saarbrücken, Germany.
Yu-Ru SuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Catherine M TangenSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Stephen N ThibodeauDivision of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Duncan C ThomasDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Sushma S ThomasPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Amanda E TolandDepartments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.ORCID http://orcid.org/0000-0002-0271-1792
Antonia TrichopoulouHellenic Health Foundation, Athens, Greece.
Cornelia M UlrichHuntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA.
David J Van Den BergDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Franzel J B van DuijnhovenDivision of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands.
Bethany Van GuelpenDepartment of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
Henk van KranenNational Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands.
Joseph VijaiDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7933-151X
Kala VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Pavel VodickaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Ludmila VodickovaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Veronika VymetalkovaDepartment of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Korbinian WeiglDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0003-4453-2036
Stephanie J WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Emily WhitePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Aung Ko WinGenomic Medicine and Family Cancer Clinic, Royal Melbourne Hospital, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-2794-5261
C Roland WolfSchool of Medicine, University of Dundee, Dundee, Scotland, UK.
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7387-6845
Michael O WoodsMemorial University of Newfoundland, Discipline of Genetics, St. John's, Newfoundland, Canada.
Anna H WuDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Syed H ZaidiOntario Institute for Cancer Research, Toronto, Ontario, Canada.
Brent W ZankeDivision of Hematology, University of Toronto, Toronto, Ontario, Canada.
Qing ZhangGenomics Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-1226-070X
Peter C ScacheriDepartment of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, OH, USA.
John D PotterPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Michael C BassikDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5185-8427
Anshul KundajeDepartment of Computer Science, Stanford University, Stanford, CA, USA.
Graham CaseyCenter for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Victor MorenoCancer Prevention and Control Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.ORCID http://orcid.org/0000-0002-2818-5487
Goncalo R AbecasisDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
Deborah A NickersonDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Stephen B GruberDepartment of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Li HsuPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. upeters@fredhutch.org.ORCID http://orcid.org/0000-0001-5666-9318

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
SWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MYLES G COCKBURN · 1985 to 2026
$181.4M
Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6M
UTAH REGIONAL CANCER CENTERP30CA042014 · NCI · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI KATHARINE S ULLMAN · 1986 to 2026
$72.6M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
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6 · The paper itself

Abstract

To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants and Haplotype Reference Consortium panel variants into genome-wide association study data, and tested for association in 34,869 cases and 29,051 controls. Findings were followed up in an additional 23,262 cases and 38,296 controls. We discovered a strongly protective 0.3% frequency variant signal at CHD1. In a combined meta-analysis of 125,478 individuals, we identified 40 new independent signals at P < 5 × 10

Indexed as

AgedCase-Control StudiesColorectal NeoplasmsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansMaleMiddle AgedPolymorphism, Single NucleotideRisk FactorsRNA, Long NoncodingSignal TransductionRNA, Long Noncoding

Identifiers

PMID30510241
PMCPMC6358437

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.