ArticleNature chemistry2019
Sequence-defined multifunctional polyethers via liquid-phase synthesis with molecular sieving.
Article in Nature chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- A Support-Free Strategy to Synthesize Sequence-Defined Macromolecules Using Solvent-Resistant Nanofiltration.Precision chemistry · 2026Article
- Toward Chromatography-Free Convergent Peptide Synthesis via Nanostar Sieving.Organic process research & development · 2026Article
- Controlled Optically Active Hierarchical Nanostructures of Side-Chain Sequence-Regulated Graphene Nanoribbons.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Cyclover-Assisted Liquid-Phase Peptide Synthesis Using T3P® as a Green Coupling Reagent.Organic letters · 2026Article
- Article
- Precise placement of thioester bonds into sequence-controlled polymers containing ABAC-type units.Nature communications · 2025Article
- Exactly defined molecular weight poly(ethylene glycol) allows for facile identification of PEGylation sites on proteins.Nature communications · 2024Article
- Solid-Phase Synthesis of Well-Defined Multiblock Copolymers by Atom Transfer Radical Polymerization.Journal of the American Chemical Society · 2024Article
- Sequence-encoded bioactive protein-multiblock polymer conjugates via quantitative one-pot iterative living polymerization.Nature communications · 2024Article
- Revealing the Effect of Stereocontrol on Intermolecular Interactions between Abiotic, Sequence-Defined Polyurethanes and a Ligand.ACS biomaterials science & engineering · 2024Article
- Striving for Uniformity: A Review on Advances and Challenges To Achieve Uniform Polyethylene Glycol.Organic process research & development · 2024Review
- Organic Solvent Nanofiltration in Pharmaceutical Applications.Organic process research & development · 2024Review
- High-Throughput Synthesis, Purification, and Application of Alkyne-Functionalized Discrete Oligomers.Journal of the American Chemical Society · 2024Article
- Discrete Oligocarbamates Exhibit Sequence-Dependent Fluorescence Emission and Quenching.ACS polymers Au · 2023Article
- Efficient transfected liposomes co-loaded with pNrf2 and pirfenidone improves safe delivery for enhanced pulmonary fibrosis reversion.Molecular therapy. Nucleic acids · 2023Article
- Design of Microstructure-Engineered Polymers for Energy and Environmental Conservation.JACS Au · 2023Review
- Iridium-Catalyzed Synthesis of Chiral 1,2,3-Triazoles Units and Precise Construction of Stereocontrolled Oligomers.Molecules (Basel, Switzerland) · 2023Article
- Multistep sequence-controlled supramolecular polymerization by the combination of multiple self-assembly motifs.iScience · 2023Article
- Nondestructive Sequencing of Enantiopure Oligoesters by Nuclear Magnetic Resonance Spectroscopy.JACS Au · 2022Article
- Molecular data storage with zero synthetic effort and simple read-out.Scientific reports · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synthetic chemists have devoted tremendous effort towards the production of precision synthetic polymers with defined sequences and specific functions. However, the creation of a general technology that enables precise control over monomer sequence, with efficient isolation of the target polymers, is highly challenging. Here, we report a robust strategy for the production of sequence-defined synthetic polymers through a combination of liquid-phase synthesis and selective molecular sieving. The polymer is assembled in solution with real-time monitoring to ensure couplings proceed to completion, on a three-armed star-shaped macromolecule to maximize efficiency during the molecular sieving process. This approach is applied to the construction of sequence-defined polyethers, with side-arms at precisely defined locations that can undergo site-selective modification after polymerization. Using this versatile strategy, we have introduced structural and functional diversity into sequence-defined polyethers, unlocking their potential for real-life applications in nanotechnology, healthcare and information storage.
Identifiers
30510218What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.