Evidence map›Paper›PMID 30510194›Full record

ArticleNature chemical biology2019

Crystal structure of misoprostol bound to the labor inducer prostaglandin E

Martin Audet, Kate L White, Billy Breton, Barbara Zarzycka, Gye Won Han, Yan Lu, Cornelius Gati, Alexander Batyuk, Petr Popov, Jeffrey Velasquez and 9 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. G Protein-Coupled Receptor-Ligand Pose and Functional Class Prediction.International journal of molecular sciences · 2024
    Article
  7. Structures of human prostaglandin FNature communications · 2023
    Article
  8. Article
  9. Article
  10. Reactions to Misoprostol: A Case Report.Clinical medicine insights. Case reports · 2023
    Article
  11. Serial femtosecond crystallography.Nature reviews. Methods primers · 2022
    Article
  12. Review
  13. Molecular basis for lipid recognition by the prostaglandin DProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Martin AudetDepartments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA.
Kate L WhiteDepartments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA.
Billy BretonDomain Therapeutics NA Inc., Montreal, Canada.
Barbara ZarzyckaDepartments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA.
Gye Won HanDepartments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA.
Yan LuiHuman Institute, ShanghaiTech University, Shanghai, China.
Cornelius GatiBiosciences Division, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.
Alexander BatyukLinac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.ORCID http://orcid.org/0000-0002-9393-2880
Petr PopovDepartments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA.
Jeffrey VelasquezDepartments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA.
David ManahanDepartments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA.
Hao HuBiodesign Center for Applied Structural Discovery, Biodesign Institute, School of Molecular Sciences, Arizona State University, Tempe, AZ, USA.
Uwe WeierstallBiodesign Center for Applied Structural Discovery, Biodesign Institute, School of Molecular Sciences, Arizona State University, Tempe, AZ, USA.
Wei LiuBiodesign Center for Applied Structural Discovery, Biodesign Institute, School of Molecular Sciences, Arizona State University, Tempe, AZ, USA.
Wenqing ShuiiHuman Institute, ShanghaiTech University, Shanghai, China.
Vsevolod KatritchDepartments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-3883-4505
Vadim CherezovDepartments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-5265-3914
Michael A HansonGPCR Consortium, San Marcos, CA, USA.
Raymond C StevensDepartments of Biological Sciences and Chemistry, Bridge Institute, Michelson Center for Convergent Bioscience, University of Southern California, Los Angeles, CA, USA. stevens@usc.edu.ORCID http://orcid.org/0000-0002-4522-8725
University of Southern California · USArizona State University · USShanghaiTech University · CNClinical Research Consortium · USPalo Alto University · USSLAC National Accelerator Laboratory · US

Funding

Structural Biology Of G Protein-Coupled ReceptorsR35GM127086 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Vadim Cherezov · 2018 to 2026
$3.6M
Structure Determination of G Protein-Coupled Receptors by Microcrystal Electron DiffractionR01GM124152 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI NANNENGA, BRENT · 2017 to 2021
$1.6M
HT structure determination of GPCRs by LCP serial femtosecond nanocrystallographyR01GM108635 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEREZOV, VADIM · 2014 to 2017
$1.5M
Structure and Function of Dopamine ReceptorsR21DA042298 · NIDA · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI LIU, WEI · 2017 to 2018
$404k
NIDA NIH HHS R21 DA042298NIGMS NIH HHS R01 GM108635NIGMS NIH HHS R01 GM124152NIGMS NIH HHS R35 GM127086
6 · The paper itself

Abstract

Misoprostol is a life-saving drug in many developing countries for women at risk of post-partum hemorrhaging owing to its affordability, stability, ease of administration and clinical efficacy. However, misoprostol lacks receptor and tissue selectivities, and thus its use is accompanied by a number of serious side effects. The development of pharmacological agents combining the advantages of misoprostol with improved selectivity is hindered by the absence of atomic details of misoprostol action in labor induction. Here, we present the 2.5 Å resolution crystal structure of misoprostol free-acid form bound to the myometrium labor-inducing prostaglandin E

Indexed as

Binding SitesCrystallography, X-RayDinoprostoneHumansMisoprostolMolecular Docking SimulationMutagenesis, Site-DirectedProtein ConformationReceptors, Prostaglandin E, EP3 SubtypeSignal TransductionWaterDinoprostoneMisoprostolPTGER3 protein, humanReceptors, Prostaglandin E, EP3 SubtypesulprostoneWater

Identifiers

PMID30510194
PMCPMC6289721
OpenAlexW2902663357

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.