ArticleNature communications2018
B cells inhibit bone formation in rheumatoid arthritis by suppressing osteoblast differentiation.
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Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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100 citing papers in PubMed.
- Targeting the immune-metabolic axis reverses orthodontics-induced systemic pathology.Signal transduction and targeted therapy · 2026Article
- NLRC5 Deficiency Delays Bone Healing by Inhibiting Osteogenic Differentiation of Bone Marrow-Derived Stem Cells and Altering the Immune Microenvironment.International journal of molecular sciences · 2026Article
- Inflammation-Driven Lymphoid Structures: Organization, Function, and Clinical Impact Across Autoimmunity, Cancer, and Checkpoint Toxicity.Immunological reviews · 2026Review
- Mechanical Force Promotes Mitochondrial Transfer From Macrophages to BMSCs to Enhance Bone Formation.Cell proliferation · 2026Article
- Aging-induced decrease in progenitor B cells enhances the osteoclastogenesis of bone marrow macrophages via ROS-activated Fos/CCL3 signaling pathway.Immunity & ageing : I & A · 2026Article
- The CNS Meninges and the Synovial Joint: Parallel Immunological Structures in Autoimmune Disease.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Gene screening and immune phenotype shifts of osteoporosis.Scientific reports · 2026Article
- Folic Acid Targeting Shared Sepsis-Osteoporosis Pathogenesis: From Computational Discovery to Dynamic Binding Mechanisms.ACS omega · 2026Article
- From Systemic Autoimmunity to the Local Immune Niche of the Synovium: New Insights into the Development of Rheumatoid Arthritis.Journal of inflammation research · 2026Review
- Bone mineral density and trabecular bone score in adults with primary immunodeficiencies: a cross-sectional study.Frontiers in endocrinology · 2026Article
- The Crosstalk Between B Cells and the Skeletal System During Development, Aging, and in Pathological Conditions.Current osteoporosis reports · 2025Review
- Interactions between the gut microbiota and immune cell dynamics: novel insights into the gut-bone axis.Gut microbes · 2025Review
- Review
- Antigen-specific B cell response regulation by IL-10-producing tolerogenic dendritic cells.Science advances · 2025Article
- Potential mechanisms of acupuncture treatment for rheumatoid arthritis: a study based on network topology and machine learning.Chinese medicine · 2025Article
- Unraveling the mechanisms of bone diseases: targeting dendritic cells in osteoimmunology for internal homeostasis balance.Bone research · 2025Review
- Advancement in smart bone implants: the latest multifunctional strategies and synergistic mechanisms for tissue repair and regeneration.Bioactive materials · 2025Review
- Angiogenesis in rheumatoid Arthritis: Pathological characterization, pathogenic mechanisms, and nano-targeted therapeutic strategies.Bioactive materials · 2025Review
- Augmentation of PRDX1-DOK3 interaction alleviates rheumatoid arthritis progression by suppressing plasma cell differentiation.Acta pharmaceutica Sinica. B · 2025Article
- Causal relationship between immune cells and osteoporosis based on genetic prediction: a bidirectional two-sample mediated Mendelian randomization analysis.Scientific reports · 2025Article
40 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Wen SunDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Nida MeednuDivision of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Alexander RosenbergDivision of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Javier Rangel-MorenoDivision of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Victor WangDivision of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.ORCID http://orcid.org/0000-0002-9649-2411
Jason GlanzmanDivision of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Teresa OwenDivision of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Xichao ZhouDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Hengwei ZhangDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Brendan F BoyceDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA.
Jennifer H AnolikDivision of Allergy, Immunology and Rheumatology, Department of Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA. jennifer_anolik@urmc.rochester.edu.
Lianping XingDepartment of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, 14642, USA. Lianping_xing@urmc.rochester.edu.
Funding
Role of B Cells in Synovial Inflammation & LN Remodeling in RA ArthritisP01AI078907 · NIAID · UNIVERSITY OF ROCHESTER · PI WU, HULIN · 2010 to 2014
$10.8MStudies on the fate of the OsteoclastR01AR043510 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI BOYCE, BRENDAN F · 1995 to 2025
$8.4MRochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8MCellular Dynamics at the Synovium-Bone interface in RAUH2AR067690 · NIAMS · UNIVERSITY OF ROCHESTER · PI ANOLIK, JENNIFER HOWITT · 2014 to 2020
$3.0MStudies of TRAF3 in age-related low-level chronic inflammation and osteoporosisR01AG049994 · NIA · UNIVERSITY OF ROCHESTER · PI BOYCE, BRENDAN F, YAO, ZHENQIANG · 2016 to 2020
$1.6MStudy of osteoblast regulation in TNF-mediated bone lossR01AR063650 · NIAMS · UNIVERSITY OF ROCHESTER · PI XING, LIANPING · 2013 to 2016
$1.4MProtein modification in bone cell regulationR21AR069789 · NIAMS · UNIVERSITY OF ROCHESTER · PI BOECKMAN, ROBERT K, XING, LIANPING · 2016 to 2017
$372kLaser Capture as a Novel Tool to Dissect B Cell Roles in Rheumatoid ArthritisR21AR071670 · NIAMS · UNIVERSITY OF ROCHESTER · PI ANOLIK, JENNIFER HOWITT · 2017 to 2018
$367kOlympus NanoZoomer RS Whole Slide Imaging SystemS10RR027340 · NCRR · UNIVERSITY OF ROCHESTER · PI BOYCE, BRENDAN F · 2010 to 2010
$340kNCRR NIH HHS S10 RR027340NIAID NIH HHS P01 AI078907NIAMS NIH HHS P30 AR069655NIAMS NIH HHS R01 AR043510NIAMS NIH HHS R01 AR063650NIAMS NIH HHS R21 AR069789NIAMS NIH HHS R21 AR071670NIAMS NIH HHS UH2 AR067690NIA NIH HHS R01 AG049994
Abstract
The function of B cells in osteoblast (OB) dysfunction in rheumatoid arthritis (RA) has not been well-studied. Here we show that B cells are enriched in the subchondral and endosteal bone marrow (BM) areas adjacent to osteocalcin
Indexed as
AnimalsArthritis, ExperimentalArthritis, RheumatoidB-LymphocytesBone MarrowCell DifferentiationHumansMaleMice, Inbred DBAMice, KnockoutMice, TransgenicOsteoblastsOsteogenesisSignal TransductionTumor Necrosis Factor-alphaTumor Necrosis Factor-alpha
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.