ArticleTranslational psychiatry2018
Childhood adversity and DNA methylation in two population-based cohorts.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Pooled it
- How are social determinants of health integrated into epigenetic research? A systematic review.Social science & medicine (1982) · 2021Pooled it
- A systematic review of childhood maltreatment and DNA methylation: candidate gene and epigenome-wide approaches.Translational psychiatry · 2021Pooled it
- Differential methylation as a diagnostic biomarker of rare renal diseases: a systematic review.BMC nephrology · 2019Pooled it
- Long-term molecular embedding of early life adversity: leukocyte DNA methylation and gene expression associations from childhood to young adulthood.Epigenomics · 2026Article
- The Danish Region Midt Schizophrenia Cohort - Representative, long-term follow-up of first-episode schizophrenia spectrum disorder.Acta neuropsychiatrica · 2026Article
- The STROBE guidelines and the Αristotelian mesotes curve.Hormones (Athens, Greece) · 2026Article
- Early life trauma patterns and adult epigenome-wide and NR3C1-specific DNA methylation in the Sister Study.American journal of epidemiology · 2026Article
- Differential Methylation by Early Life Adversity in the Future of Families Child Wellbeing Study.bioRxiv : the preprint server for biology · 2026Article
- Loss, inflammation, and cognition: Understanding the lifecourse impact of early life parental disruption.Social science & medicine (1982) · 2026Article
- Associations of parental labour migration and childhood maltreatment with psychosocial health among adolescents and young adults in China.European journal of psychotraumatology · 2025Article
- Cross-Tissue Specificity of Pediatric DNA Methylation Associated With Cumulative Family Stress.Developmental psychobiology · 2025Article
- Mediation of DNA methylation (cg04622888 and cg05037505) in the association between childhood maltreatment and non-suicidal self-injury in early adolescents.European child & adolescent psychiatry · 2025Article
- Epigenetics in persons living with HIV: trauma, coping, andEpigenomics · 2025Article
- Molecular insights into trauma: A framework of epigenetic pathways to resilience through intervention.Med (New York, N.Y.) · 2025Review
- Adverse childhood experiences, mental distress, and autoimmune disease in adult women: findings from two large cohort studies.Psychological medicine · 2025Article
- Impacts of Polyenvironmental Factors on DNA Methylation in Patients With Psychosis.Schizophrenia bulletin open · 2025Article
- Epigenome-wide mediation analysis of the relationship between psychosocial stress and cardiometabolic risk factors in the Health and Retirement Study (HRS).Clinical epigenetics · 2024Article
- Epigenome-wide association study of long-term psychosocial stress in older adults.Epigenetics · 2024Article
- DNA methylation signatures of early-life adversity are exposure-dependent in wild baboons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
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8 authors.
Funding
Abstract
Childhood adversity affects later health, but the underlying molecular mechanisms are unclear. Although there is some evidence from animal models and case-control studies of a role for DNA methylation, evidence from human population-based studies is limited. In two cohorts (mothers from the Avon Longitudinal Study of Parents and Children, ALSPAC, n = 780 and women from the MRC National Survey of Health and Development, NSHD, n = 552), we assessed the association of seven adverse childhood experiences (ACEs: parental physical illness, parental mental illness, parental death, parental separation, suboptimal maternal bonding, childhood illness and child maltreatment) as well as their combination (ACE score) with genome-wide DNA methylation levels measured using the Illumina Infinium HumanMethylation450 BeadChip in peripheral blood at mean age 47 years (ALSPAC) and in buccal cells at age 53 years (NSHD). CpG sites with a genome-wide false discovery rate (FDR) below 0.05 and differentially methylated regions (DMRs) with one-step Šidák correction p-values below 0.05 in each cohort were examined in the other cohort. No individual CpG sites replicated across cohorts. However, nine DMRs replicated across cohorts respectively associated with the ACE score (one region), parental mental illness (two regions), parental physical illness (three regions) and parental death (three regions). These observations indicate that some adverse childhood experiences, notably those related to parental health, may leave imprints on peripheral DNA methylation that persist to mid-life.
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