Evidence map›Paper›PMID 30510157›Full record

SynthesisNature communications2018

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Nora Franceschini, Claudia Giambartolomei, Paul S de Vries, Chris Finan, Joshua C Bis, Rachael P Huntley, Ruth C Lovering, Salman M Tajuddin, Thomas W Winkler, Misa Graff and 149 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
114citing papers in PubMed, 5 pooled it
12.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

114 citing papers in PubMed, 5 syntheses or guidelines pooled it, 177 citations in OpenAlex.

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  11. Leveraging Mendelian randomization to inform drug discovery and development for ischemic stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
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54 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

159 authors at 20 institutions in 23 countries.

Nora FranceschiniDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA.
Claudia GiambartolomeiDepartment of Pathology and Laboratory Medicine, University of California (UCLA), Los Angeles, Los Angeles, CA, 90095, USA.ORCID http://orcid.org/0000-0003-2786-1225
Paul S de VriesHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Chris FinanInstitute of Cardiovascular Science, University College London, London, WC1 6BT, UK.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.
Rachael P HuntleyInstitute of Cardiovascular Science, University College London, London, WC1 6BT, UK.ORCID http://orcid.org/0000-0001-6718-3559
Ruth C LoveringInstitute of Cardiovascular Science, University College London, London, WC1 6BT, UK.ORCID http://orcid.org/0000-0002-9791-0064
Salman M TajuddinLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 20892, USA.ORCID http://orcid.org/0000-0002-7919-8528
Thomas W WinklerDepartment of Genetic Epidemiology, University of Regensburg, Regensburg, 93053, Germany.ORCID http://orcid.org/0000-0003-0292-5421
Misa GraffDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA.
Maryam KavousiDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.
Caroline DaleInstitute of Health Informatics, University College London, London, WC1E 6BT, UK.
Albert V SmithIcelandic Heart Association, Kopavogur, IS-201, Iceland.
Edith HoferClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036, Austria.
Elisabeth M van LeeuwenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.
Ilja M NolteDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 3015, The Netherlands.ORCID http://orcid.org/0000-0001-5047-4077
Lingyi LuDepartment of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, , University of Leipzig, Leipzig, 04107, Germany.ORCID http://orcid.org/0000-0002-4059-1779
Muralidharan SargurupremrajUniv. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, F-33000, Bordeaux, France.
Niina PitkänenResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland.
Oscar FranzénDepartment of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Peter K JoshiUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.ORCID http://orcid.org/0000-0002-6361-5059
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300, RC, The Netherlands.
Riccardo E MarioniCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
Shih-Jen HwangPopulation Sciences Branch, Division of Intramural Research, NHLBI, NIH, Framingham, MA, 01702-5827, USA.
Solomon K MusaniDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Ulf SchminkeDepartment of Neurology, University Medicine Greifswald, Greifswald, 17475, Germany.
Walter PalmasDepartment of Medicine, Columbia University, New York, NY, 10032, USA.
Aaron IsaacsDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.ORCID http://orcid.org/0000-0001-5037-4834
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA.ORCID http://orcid.org/0000-0002-9501-600X
Alan B ZondermanLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 20892, USA.
Albert HofmanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, 17475, Germany.ORCID http://orcid.org/0000-0002-8309-094X
Amanda J CoxCenter for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, 25157, USA.
André G UitterlindenDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.
Andrew WongMRC Unit for Lifelong Health and Ageing at UCL, London, WC1E 6BT, UK.ORCID http://orcid.org/0000-0003-2079-4779
Andries J SmitDepartment of Medicine, University of Groningen, University Medical Center Groningen, Groningen, 2300, The Netherlands.
Anne B NewmanDepartment of Epidemiology, and School of Medicine, Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA.ORCID http://orcid.org/0000-0002-0106-1150
Annie BrittonDepartment of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK.
Arno RuusaleppClinical Gene Networks AB, Stockholm, 104 62, Sweden.
Bengt SennbladCardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, 17177, Sweden.ORCID http://orcid.org/0000-0002-4360-8003
Bo HedbladDepartment of Clinical Sciences in Malmö, Lund University, Malmö, SE-205 02, Sweden.
Bogdan PasaniucDepartment of Pathology and Laboratory Medicine, University of California (UCLA), Los Angeles, Los Angeles, CA, 90095, USA.
Brenda W PenninxDepartment of Psychiatry, EMGO Institute for Health and Care Research and Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, 1081, HL, The Netherlands.
Carl D LangefeldDepartment of Biostatistical Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Christina L WasselApplied Sciences, Premier, Inc., Charlotte, NC, 28277, USA.
Christophe TzourioUniv. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, F-33000, Bordeaux, France.
Cristiano FavaDepartment of Clinical Sciences in Malmö, Lund University, Malmö, SE-205 02, Sweden.
Damiano BaldassarreDepartment of Medical Biotechnology and Translational Medicine, Università di Milano, Milan, 20133, Italy.ORCID http://orcid.org/0000-0002-2766-8882
Daniel H O'LearySt. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, 02135, USA.
Daniel TeupserLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany.
Diana KuhMRC Unit for Lifelong Health and Ageing at UCL, London, WC1E 6BT, UK.ORCID http://orcid.org/0000-0001-7386-2857
Elena TremoliCentro Cardiologico Monzino, IRCCS, Milan, 20138, Italy.
Elmo MannarinoDepartment of Clinical and Experimental Medicine, Internal Medicine, Angiology and Arteriosclerosis Diseases, University of Perugia, Perugia, 06123, Italy.
Enzo GrossiCentro Diagnostico Italiano, Milan, 20147, Italy.
Eric BoerwinkleHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Eric E SchadtDepartment of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0002-7892-8808
Erik IngelssonDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, 94309, USA.
Fabrizio VegliaCentro Cardiologico Monzino, IRCCS, Milan, 20138, Italy.
Fernando RivadeneiraDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.ORCID http://orcid.org/0000-0001-9435-9441
Frank BeutnerHeart Center Leipzig, Leipzig, 04103, Germany.
Ganesh ChauhanUniv. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, F-33000, Bordeaux, France.
Gerardo HeissDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 3015, The Netherlands.
Harry CampbellUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, 17475, Germany.
Hugh S MarkusStroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, 2300, RC, The Netherlands.ORCID http://orcid.org/0000-0002-3246-8359
Jacqueline de GraafDepartment of Internal Medicine, Radboud University Medical Center, Nijmegen, 6525, GA, The Netherlands.
Jacqueline PriceUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.
Janne PottInstitute for Medical Informatics, Statistics and Epidemiology, , University of Leipzig, Leipzig, 04107, Germany.
Jemma C HopewellClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Jingjing LiangDepartment of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Joachim ThieryLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany.
Jorgen EngmannInstitute of Cardiovascular Science, University College London, London, WC1 6BT, UK.
Karl GertowCardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, 17177, Sweden.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, WA, 98105, USA.ORCID http://orcid.org/0000-0002-3071-7278
Kent D TaylorInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Klodian DhanaDepartment of Internal Medicine, Rush University Medical Center, Chicago, IL, 60612, USA.ORCID http://orcid.org/0000-0002-6397-7009
Lambertus A L M KiemeneyRadboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, GA, 6525, The Netherlands.
Lars LindDepartment of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, Uppsala, 751 05, Sweden.
Laura M RaffieldDepartment of Genetics, University of North Carolina, Chapel Hill, NC, 27516, USA.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 20892, USA.
Lesca M HoldtLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany.
Marcus DörrDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.
Martin DichgansInstitute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Munich, 80539, Germany.ORCID http://orcid.org/0000-0002-0654-387X
Matthew TraylorStroke Research Group, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK.ORCID http://orcid.org/0000-0001-6624-8621
Matthias SitzerDepartment of Neurology, Center for Neurology and Neurosurgery, Johann Wolfgang Goethe-University, Frankfurt am Main, 60323, Germany.
Meena KumariDepartment of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK.
Mika KivimakiDepartment of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK.ORCID http://orcid.org/0000-0002-4699-5627
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.
Olle MelanderDepartment of Clinical Sciences in Malmö, Lund University, Malmö, SE-205 02, Sweden.
Olli RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland.
Oscar H FrancoDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.
Oscar L Rueda-OchoaDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.
Panos RoussosDepartment of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0002-4640-6239
Peter H WhincupPopulation Health Research Institute, St George's, University of London, London, SW17 0RE, UK.
Philippe AmouyelInserm U1167, F-59000, Lille, France.ORCID http://orcid.org/0000-0001-9088-234X
Philippe GiralSorbonne Université, Cardiovascular Prevention Unit, Pitié Salpétrière Hospital, Paris, 75013, France.
Pramod AnuguDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Quenna WongCollaborative Health Studies Coordinating Center, Department of Biostatistics, University of Washington, Seattle, WA, 98195, USA.
Rainer MalikInstitute for Stroke and Dementia Research (ISD), University Hospital, Ludwig-Maximilians-University (LMU), Munich, 80539, Germany.
Rainer RauramaaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, 70100, Finland.
Ralph BurkhardtLIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, 04107, Germany.ORCID http://orcid.org/0000-0003-1924-1202
Rebecca HardyMRC Unit for Lifelong Health and Ageing at UCL, London, WC1E 6BT, UK.
Reinhold SchmidtClinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, 8036, Austria.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.
Richard W MorrisDepartment of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 1QU, UK.ORCID http://orcid.org/0000-0001-7240-4563
Rona J StrawbridgeCardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, 17177, Sweden.
S Goya WannametheeDepartment of Primary Care & Population Health, University College London, London, WC1E 6BT, UK.
Sara HäggDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.ORCID http://orcid.org/0000-0002-2452-1500
Sonia ShahInstitute of Cardiovascular Science, University College London, London, WC1 6BT, UK.
Stela McLachlanUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.
Stella TrompetDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, 2300, RC, The Netherlands.
Sudha SeshadriDepartment of Neurology, Boston University School of Medicine, Boston, MA, 02118, USA.
Sudhir KurlInstitute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, FI-70210, Finland.
Susan R HeckbertCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, 98101, USA.
Susan RingPopulation Health Science, Bristol Medical School, University of Bristol, Bristol, BS8 1QU, UK.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 20892, USA.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, 33014, Finland.
Tessel E GaleslootRadboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, GA, 6525, The Netherlands.
Tina ShahInstitute of Cardiovascular Science, University College London, London, WC1 6BT, UK.
Ulf de FaireDivision of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, S-171 77, Sweden.
Vincent PlagnolGenetics Institute, University College London, London, WC1E 6BT, UK.
Wayne D RosamondDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC, 27516, USA.
Wendy PostDepartments of Medicine and Epidemiology, Johns Hopkins University, Baltimore, MD, 21205, USA.
Xiaofeng ZhuDepartment of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA.
Xiaoling ZhangNational Heart, Lung and Blood Institute's Intramural Research Program, Framingham Heart Study, Framingham, MA, 01702-5827, USA.
Xiuqing GuoInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Yasaman SabaInstitute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, 8010, Austria.
MEGASTROKE Consortium
Abbas DehghanDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.
Adrie SeldenrijkGGZ inGeest and Amsterdam Public Health Research Institute, Department of Psychiatry, Amsterdam University Medical Center, Amsterdam, 1081 HV, The Netherlands.
Alanna C MorrisonHuman Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.
Anders HamstenCardiovascular Medicine Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, 17177, Sweden.
Bruce M PsatyKaiser Permanente Washington Health Research Institute, Seattle, WA, 98101, USA.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, The Netherlands.
Deborah A LawlorPopulation Health Science, Bristol Medical School, University of Bristol, Bristol, BS8 1QU, UK.ORCID http://orcid.org/0000-0002-6793-2262
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, 2333, The Netherlands.
Donald W BowdenCenter for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Helena SchmidtInstitute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, 8010, Austria.
James F WilsonUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, EH8 9AG, UK.ORCID http://orcid.org/0000-0001-5751-9178
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, 39216, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Joanna M WardlawCentre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, EH8 9JZ, UK.ORCID http://orcid.org/0000-0002-9812-6642
John DeanfieldInstitute of Cardiovascular Science, University College London, London, WC1 6BT, UK.
Julian HalcoxSwansea University Medical School, Swansea, SA2 8PP, UK.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere, 33014, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Markus LoefflerInstitute for Medical Informatics, Statistics and Epidemiology, , University of Leipzig, Leipzig, 04107, Germany.
Michele K EvansLaboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, 20892, USA.
Stéphanie DebetteUniv. Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, F-33000, Bordeaux, France.
Steve E HumphriesCentre for Cardiovascular Genetics, Institute Cardiovascular Science, University College London, London, WC1E 6BT, UK.
Uwe VölkerDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, 17475, Germany.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur, IS-201, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
Aroon D HingoraniInstitute of Cardiovascular Science, University College London, London, WC1 6BT, UK.
Johan L M BjörkegrenDepartment of Genetics and Genomic Sciences, The Icahn Institute for Genomics and Multiscale Biology Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. johan.bjorkegren@mssm.edu.
Juan P CasasInstitute of Health Informatics, University College London, London, WC1E 6BT, UK.
Christopher J O'DonnellIntramural Administration Management Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 20892, USA. Christopher.ODonnell@va.gov.
Broad Institute · USNational Institutes of Health · USErasmus MC · NLLeiden University Medical Center · NLInserm · FRMedical University of Graz · ATUniversity of Cambridge · GBUniversity of North Carolina at Chapel Hill · USdeCODE Genetics (Iceland) · ISKarolinska Institutet · SEUniversité de Bordeaux · FRUniversity College London · GBUniversity of Washington · USBoston University · USHarvard University · USKyushu University · JPUniversitat Autònoma de Barcelona · ESUniversitätsmedizin Greifswald · DEUniversity of Maryland, Baltimore · USUppsala University · SE

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
Resource ProjectU41HG002273 · NHGRI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMAS, PAUL D. · 2012 to 2021
$34.7M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
The Underlying Biology of Health DisparitiesZIAAG000519 · NIA · NATIONAL INSTITUTE ON AGING · PI EVANS, MICHELE K · 2009 to 2025
$15.7M
Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
CHS research resources for the cardiovascular health of older adultsU01HL130114 · NHLBI · UNIVERSITY OF WASHINGTON · PI BURKE, GREGORY L, KRONMAL, RICHARD A · 2016 to 2019
$6.6M
Methods for Genome-wide Association Studies in Admixed PopulationsR01HG006399 · NHGRI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI PRICE, ALKES L · 2011 to 2024
$6.3M
CLINICAL PROJECT: Age, Gene/Environment Susceptibility Study on the Multi-omics of Aging: A clinical epidemiologic prospective studyZIAAG007380 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2009 to 2025
$6.1M
British Heart Foundation FS/14/55/30806British Heart Foundation PG/09/024/26857British Heart Foundation PG/13/66/30442British Heart Foundation RG/13/13/30194British Heart Foundation RG/13/16/30528British Heart Foundation RG/13/5/30112Department of Health 01/37/03Medical Research Council G0701120Medical Research Council G1001245Medical Research Council G1001357Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_12013/5Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12019/2Medical Research Council MR/K013351/1Medical Research Council MR/K026992/1Medical Research Council MR/L003120/1Medical Research Council MR/M006638/1Medical Research Council MR/M013111/1Medical Research Council MR/R024227/1Medical Research Council MR/S003061/1NCI NIH HHS U01 CA194393NHGRI NIH HHS R01 HG006399NHGRI NIH HHS R01 HG009120NHGRI NIH HHS U41 HG002273NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R21 HL123677NHLBI NIH HHS R21 HL140385NHLBI NIH HHS T32 HL129982NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIA NIH HHS P30 AG010129NIA NIH HHS R01 AG054076NIA NIH HHS U01 AG052409NIDDK NIH HHS P30 DK079626NIDDK NIH HHS R01 DK117445NIDDK NIH HHS R56 DK104806NIGMS NIH HHS U54 GM115428NIMHD NIH HHS R01 MD012765NINDS NIH HHS R01 NS017950NINDS NIH HHS T32 NS048004NINDS NIH HHS UH3 NS100605
6 · The paper itself

Abstract

Carotid artery intima media thickness (cIMT) and carotid plaque are measures of subclinical atherosclerosis associated with ischemic stroke and coronary heart disease (CHD). Here, we undertake meta-analyses of genome-wide association studies (GWAS) in 71,128 individuals for cIMT, and 48,434 individuals for carotid plaque traits. We identify eight novel susceptibility loci for cIMT, one independent association at the previously-identified PINX1 locus, and one novel locus for carotid plaque. Colocalization analysis with nearby vascular expression quantitative loci (cis-eQTLs) derived from arterial wall and metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4. LD score regression reveals significant genetic correlations between cIMT and plaque traits, and both cIMT and plaque with CHD, any stroke subtype and ischemic stroke. Our study provides insights into genes and tissue-specific regulatory mechanisms linking atherosclerosis both to its functional genomic origins and its clinical consequences in humans.

Indexed as

Carotid Intima-Media ThicknessADAMTS9 ProteinAmino Acid OxidoreductasesCoronary DiseaseGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLod ScorePlaque, AtheroscleroticPolymorphism, Single NucleotideProtein-Lysine 6-OxidaseQuantitative Trait LociRisk FactorsADAMTS9 ProteinADAMTS9 protein, humanAmino Acid OxidoreductasesLOXL4 protein, humanProtein-Lysine 6-Oxidase

Identifiers

PMID30510157
PMCPMC6277418
OpenAlexW2903416893

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.