Observational studyJournal of the American Society of Nephrology : JASN2019
Sex-Related Disparities in CKD Progression.
Observational study in Journal of the American Society of Nephrology : JASN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 185 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
185 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Rat models for arterial calcification associated with chronic kidney disease: a systematic review and meta-analysis.BMC cardiovascular disorders · 2026Pooled it
- Sexually dimorphic response to tobacco in the development of chronic kidney disease: a systematic review.BMC nephrology · 2024Pooled it
- GFR in Healthy Aging: an Individual Participant Data Meta-Analysis of Iohexol Clearance in European Population-Based Cohorts.Journal of the American Society of Nephrology : JASN · 2020Pooled it
- Trial
- Finerenone Improves Outcomes in Patients With Heart Failure With Mildly Reduced or Preserved Ejection Fraction Irrespective of Age: A Prespecified Analysis of FINEARTS-HF.Circulation. Heart failure · 2024Trial
- Effects of Dapagliflozin in Chronic Kidney Disease Across the Spectrum of Age and by Sex.Journal of general internal medicine · 2024Trial
- Development of a risk prediction score and equation for chronic kidney disease: a retrospective cohort study.Scientific reports · 2023Trial
- Article
- Authors' Reply: Interpreting Biomarker Adjustment in Sex-Associated CKD Risk.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Gender differences in long-term complications of chronic hypoparathyroidism: a systematic review.Journal of endocrinological investigation · 2026Review
- Sex differences in renal acid-base regulation.Current opinion in nephrology and hypertension · 2026Review
- Sex-Specific Associations of Monocyte-Based Inflammatory Indices with Renal Dysfunction and Hyperuricemia in the Saudi General Adult Population.Healthcare (Basel, Switzerland) · 2026Article
- Efficacy of Yishen Jiangzhuo granules in the treatment of chronic kidney disease stages 3-4: a retrospective cohort study.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2026Article
- Association of IgG N-Glycans With Adverse Outcomes in CKD.Kidney international reports · 2026Article
- Frailty and incident cognitive impairment in patients with CKD: sex-frailty paradox in the Chronic Renal Insufficiency Cohort (CRIC).GeroScience · 2026Article
- Renal Tubule Cell-SpecificHypertension (Dallas, Tex. : 1979) · 2026Article
- Sex Differences in 6-Year Change in eGFR and ACR in a Multiethnic Population: The HELIUS Study.Kidney medicine · 2026Article
- Risk of Hospital Readmission among People with CKD: A Population-Based Cohort Study.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Review
- Challenges and knowledge gaps in sex differences in cardio-kidney-metabolic syndrome across the lifespan.Biology of sex differences · 2026Review
125 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundIn the United States, incidence of ESRD is 1.5 times higher in men than in women, despite men's lower prevalence of CKD. Prior studies, limited by inclusion of small percentages of minorities and other factors, suggested that men have more rapid CKD progression, but this finding has been inconsistent.
methodsIn our prospective investigation of sex differences in CKD progression, we used data from 3939 adults (1778 women and 2161 men) enrolled in the Chronic Renal Insufficiency Cohort Study, a large, diverse CKD cohort. We evaluated associations between sex (women versus men) and outcomes, specifically incident ESRD (defined as undergoing dialysis or a kidney transplant), 50% eGFR decline from baseline, incident CKD stage 5 (eGFR<15 ml/min per 1.73 m
resultsParticipants' mean age was 58 years at study entry; 42% were non-Hispanic black, and 13% were Hispanic. During median follow-up of 6.9 years, 844 individuals developed ESRD, and 853 died. In multivariable regression models, compared with men, women had significantly lower risk of ESRD, 50% eGFR decline, progression to CKD stage 5, and death. The mean unadjusted eGFR slope was -1.09 ml/min per 1.73 m
conclusionsIn this CKD cohort, women had lower risk of CKD progression and death compared with men. Additional investigation is needed to identify biologic and psychosocial factors underlying these sex-related differences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.