Evidence map›Paper›PMID 30510121›Full record

ArticleCancer research2019

Lactic Acid Accumulation in the Tumor Microenvironment Suppresses

Silvan Türkcan, Louise Kiru, Dominik J Naczynski, Laura S Sasportas, Guillem Pratx

Abstract read
In one paragraph

Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
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  12. Autoregulation of HBritish journal of cancer · 2022
    Article
  13. Review
  14. Flow radiocytometry using droplet optofluidics.Biosensors & bioelectronics · 2021
    Article
  15. Article
  16. Article
  17. Review
  18. Cell Metabolism and DNA Repair Pathways: Implications for Cancer Therapy.Frontiers in cell and developmental biology · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Silvan Türkcan *Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Louise Kiru *Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California.ORCID 0000-0003-4819-7335
Dominik J NaczynskiDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Laura S SasportasDepartment of Radiology, Stanford University School of Medicine, Stanford, California.
Guillem PratxDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California. pratx@stanford.edu.ORCID 0000-0002-0247-6470
Stanford Medicine · US

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI Melinda L. Telli · 2007 to 2026
$71.4M
Postdoctoral Training in the Radiation ScincesT32CA121940 · NCI · STANFORD UNIVERSITY · PI GRAVES, EDWARD E. · 2007 to 2018
$2.1M
Quantitative Imaging of Cancer Drug Resistance via Radioluminescence MicroarraysR01CA186275 · NCI · STANFORD UNIVERSITY · PI PRATX, GUILLEM · 2014 to 2018
$1.7M
NCI NIH HHS P30 CA124435NCI NIH HHS R01 CA186275NCI NIH HHS T32 CA121940
6 · The paper itself

Abstract

The process by which tumor cells take up 2-[

Indexed as

AnimalsBreast NeoplasmsCell HypoxiaCell Line, TumorCell ProliferationFemaleFluorodeoxyglucose F18HeterograftsHumansLactic AcidMammary Neoplasms, ExperimentalMiceMice, NudeRadiopharmaceuticalsTumor MicroenvironmentFluorodeoxyglucose F18Lactic AcidRadiopharmaceuticals

Identifiers

PMID30510121
PMCPMC6335173
OpenAlexW2902985106

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.