Evidence map›Paper›PMID 30510108›Full record

ArticleInfection and immunity2019

The SOS Response Mediates Sustained Colonization of the Mammalian Gut.

Amanda N Samuels, Manuela Roggiani, Jun Zhu, Mark Goulian, Rahul M Kohli

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Role of themBio · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. New insights into intestinal phages.Mucosal immunology · 2020
    Review
  15. Bacteriocins ofToxins · 2020
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Amanda N SamuelsSchool of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Manuela RoggianiDepartment of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jun ZhuDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-9182-5224
Mark GoulianDepartment of Biology, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA goulian@sas.upenn.edu rkohli@pennmedicine.upenn.edu.
Rahul M KohliDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA goulian@sas.upenn.edu rkohli@pennmedicine.upenn.edu.ORCID 0000-0002-7689-5678
University of Pennsylvania · US

Funding

VMD-PhD Training in Infectious Disease-Related ResearchT32AI070077 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Michael Lee Atchison · 2008 to 2026
$3.5M
The Molecular Basis for the Bacterial SOS SignalR01GM127593 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KOHLI, RAHUL MANU, PETERSSON, ERNEST JAMES · 2018 to 2021
$1.2M
E. coli niche expansion and adaptation in the dysbiotic intestineR21AI125814 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI GOULIAN, MARK D · 2016 to 2017
$443k
NIAID NIH HHS R21 AI125814NIAID NIH HHS T32 AI070077NIGMS NIH HHS R01 GM127593
6 · The paper itself

Abstract

Bacteria have a remarkable ability to survive, persist, and ultimately adapt to environmental challenges. A ubiquitous environmental hazard is DNA damage, and most bacteria have evolved a network of genes to combat genotoxic stress. This network is known as the SOS response and aids in bacterial survival by regulating genes involved in DNA repair and damage tolerance. Recently, the SOS response has been shown to play an important role in bacterial pathogenesis, and yet the role of the SOS response in nonpathogenic organisms and in physiological settings remains underexplored. Using a commensal

Indexed as

AnimalsDisease Models, AnimalDNA DamageEscherichia coliGastrointestinal TractGene Expression Regulation, BacterialMiceMice, Inbred C57BLSOS Response, Geneticsbacterial stress responseDNA damageintestinal colonizationmicrobe-host interactionmicrobe-microbe interactions

Identifiers

PMID30510108
PMCPMC6346138
OpenAlexW2902044335

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.