SynthesisThe British journal of general practice : the journal of the Royal College of General Practitioners2019
Genetic cancer risk assessment in general practice: systematic review of tools available, clinician attitudes, and patient outcomes.
Synthesis in The British journal of general practice : the journal of the Royal College of General Practitioners, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Pooled it
- General practitioners' (GPs) experience, attitudes and needs on clinical genetic services: a systematic review.Family medicine and community health · 2022Pooled it
- Current status of knowledge, diagnosis and management of hereditary colorectal cancer among physicians in China: a national questionnaire survey of 81 doctors from different hospitals.Familial cancer · 2026Article
- Current landscape of clinical genetics knowledge and attitudes among Non-Geneticist Physicians - the McGill genetics education survey (McGES).Journal of community genetics · 2025Article
- Are we ready? assessing effectiveness and implementation of cancer control strategies in primary care: a comprehensive review of systematic reviews.Family practice · 2025Review
- Article
- Utility of eConsult to enhance delivery of cancer genetic services and identify hereditary cancer knowledge gaps in primary care.Genetics in medicine open · 2025Article
- The acceptability and clinical impact of using polygenic scores for risk-estimation of common cancers in primary care: a systematic review.Journal of community genetics · 2024Review
- Workload and workflow implications associated with the use of electronic clinical decision support tools used by health professionals in general practice: a scoping review.BMC primary care · 2023Article
- Educational Programme for Cancer Nurses in Genetics, Health Behaviors and Cancer Prevention: A Multidisciplinary Consensus Study.Journal of personalized medicine · 2022Article
- Adaptation and early implementation of the PREdiction model for gene mutations (PREMMFamilial cancer · 2022Article
- Retrospective assessment of barriers and access to genetic services for hereditary cancer syndromes in an integrated health care delivery system.Hereditary cancer in clinical practice · 2022Article
- From the patient to the population: Use of genomics for population screening.Frontiers in genetics · 2022Article
- Incomplete Penetrance of Population-Based Genetic Screening Results in Electronic Health Record.Frontiers in genetics · 2022Article
- Genetic risk assessment for hereditary renal cell carcinoma: Clinical consensus statement.Cancer · 2021Article
- Should All Individuals Be Screened for Genetic Predisposition to Cancer?Genetics research · 2021Review
- The composition and capacity of the clinical genetics workforce in high-income countries: a scoping review.Genetics in medicine : official journal of the American College of Medical Genetics · 2020Article
- A regional population-based hereditary breast cancer screening tool in Italy: First 5-year results.Cancer medicine · 2020Article
- First Responder to Genomic Information: A Guide for Primary Care Providers.Molecular diagnosis & therapy · 2019Review
- Genetic cancer risk assessment in general practice: systematic review of tools available, clinician attitudes, and patient outcomes.The British journal of general practice : the journal of the Royal College of General Practitioners · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA growing demand for cancer genetic services has led to suggestions for the involvement of GPs. How, and in which conditions, they can be involved, and whether there are important barriers to implementation should be ascertained.
aimTo review the tools available, clinician attitudes and experiences, and the effects on patients of genetic cancer risk assessment in general practice. DESIGN AND
settingSystematic review of papers published worldwide between 1996 and 2017.
methodThe MEDLINE (via Ovid), EMBASE, Cochrane Library, CINAHL, and PsycINFO databases and grey literature were searched for entries dating from January 1996 to December 2017. Study quality was assessed with relevant Critical Appraisal Skills Programme tool checklists and a narrative synthesis of findings was conducted.
resultsIn total, 40 studies were included in the review. A variety of testing and screening tools were available for genetic cancer risk assessment in general practice, principally for breast, breast-ovarian, and colorectal cancer risk. GPs often reported low knowledge and confidence to engage with genetic cancer risk assessment; however, despite time pressures and concerns about confidentiality and the impact of results on family members, some recognised the potential importance relating to such a development of the GP's role. Studies found few reported benefits for patients. Concerns about negative impacts on patient anxiety and cancer worries were largely not borne out.
conclusionGPs may have a potential role in identifying patients at risk of hereditary cancer that can be facilitated by family-history tools. There is currently insufficient evidence to support the implementation of population-wide screening for genetic cancer risk, especially given the competing demands of general practice.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.