Evidence map›Paper›PMID 30510035›Full record

ArticleThe Journal of general physiology2019

Molecular dissection of multiphase inactivation of the bacterial sodium channel Na

Tamer M Gamal El-Din, Michael J Lenaeus, Karthik Ramanadane, Ning Zheng, William A Catterall

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of general physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  9. Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel NaProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  10. Article
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  14. Fenestropathy of Voltage-Gated Sodium Channels.Frontiers in pharmacology · 2022
    Review
  15. Autism-associated mutations in KProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Tamer M Gamal El-DinDepartment of Pharmacology, University of Washington, Seattle, WA.ORCID 0000-0002-7406-7393
Michael J LenaeusDepartment of Pharmacology, University of Washington, Seattle, WA.ORCID 0000-0003-1284-8052
Karthik RamanadaneDepartment of Pharmacology, University of Washington, Seattle, WA.ORCID 0000-0001-7188-0250
Ning ZhengDepartment of Pharmacology, University of Washington, Seattle, WA.
William A CatterallDepartment of Pharmacology, University of Washington, Seattle, WA wcatt@uw.edu.ORCID 0000-0003-4059-1282
University of Washington · USÉcole Normale Supérieure Paris-Saclay · FRHoward Hughes Medical Institute · US

Funding

Structural Basis for Antiarrhythmic Drug ActionR01HL112808 · NHLBI · UNIVERSITY OF WASHINGTON · PI ZHENG, NING · 2012 to 2025
$7.8M
Sodium and Calcium Channels: Structure, Function, Neuroplasticity, and DiseaseR35NS111573 · NINDS · UNIVERSITY OF WASHINGTON · PI SCOTT, JOHN D · 2019 to 2024
$6.1M
VOLTAGE-SENSITIVE SODIUM CHANNELS IN BRAINR01NS015751 · NINDS · UNIVERSITY OF WASHINGTON · PI CATTERALL, WILLIAM A · 1985 to 2018
$6.0M
Howard Hughes Medical InstituteNHLBI NIH HHS R01 HL112808NINDS NIH HHS R01 NS015751NINDS NIH HHS R35 NS111573
6 · The paper itself

Abstract

Homotetrameric bacterial voltage-gated sodium channels share major biophysical features with their more complex eukaryotic counterparts, including a slow-inactivation mechanism that reduces ion-conductance activity during prolonged depolarization through conformational changes in the pore. The bacterial sodium channel Na

Indexed as

Ion Channel GatingAnimalsBacterial ProteinsCell LineLepidopteraMembrane PotentialsMutationProtein DomainsSodium ChannelsBacterial ProteinsSodium Channels

Identifiers

PMID30510035
PMCPMC6363407
OpenAlexW2903122110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.