Evidence map›Paper›PMID 30510004›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Microbiome interactions shape host fitness.

Alison L Gould, Vivian Zhang, Lisa Lamberti, Eric W Jones, Benjamin Obadia, Nikolaos Korasidis, Alex Gavryushkin, Jean M Carlson, Niko Beerenwinkel, William B Ludington

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 302 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
302citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

302 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Principles for Rigorous Design and Application of Synthetic Microbial Communities.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  14. Association rule mining of the human gut microbiome.Science China. Life sciences · 2026
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242 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alison L GouldDivision of Genetics, Genomics & Development, Department of Molecular & Cell Biology, University of California, Berkeley, CA 94720.ORCID 0000-0002-2358-303X
Vivian ZhangDivision of Genetics, Genomics & Development, Department of Molecular & Cell Biology, University of California, Berkeley, CA 94720.
Lisa LambertiDepartment of Biosystems Science & Engineering, ETH Zurich, Zurich 8092, Switzerland.
Eric W JonesComplex Systems Group, Department of Physics, University of California, Santa Barbara, CA 93106.
Benjamin ObadiaDivision of Genetics, Genomics & Development, Department of Molecular & Cell Biology, University of California, Berkeley, CA 94720.ORCID 0000-0002-3286-3236
Nikolaos KorasidisDepartment of Biosystems Science & Engineering, ETH Zurich, Zurich 8092, Switzerland.
Alex GavryushkinDepartment of Biosystems Science & Engineering, ETH Zurich, Zurich 8092, Switzerland.
Jean M CarlsonComplex Systems Group, Department of Physics, University of California, Santa Barbara, CA 93106.
Niko BeerenwinkelDepartment of Biosystems Science & Engineering, ETH Zurich, Zurich 8092, Switzerland.
William B LudingtonDivision of Genetics, Genomics & Development, Department of Molecular & Cell Biology, University of California, Berkeley, CA 94720; ludington@carnegiescience.edu.ORCID 0000-0001-9637-4493

Funding

Developing a reduced complexity model gut microbiome in the behavior model, Drosophila melanogasterDP5OD017851 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI LUDINGTON, WILLIAM BASIL · 2013 to 2017
$2.0M
NIH HHS DP5 OD017851
6 · The paper itself

Abstract

Gut bacteria can affect key aspects of host fitness, such as development, fecundity, and lifespan, while the host, in turn, shapes the gut microbiome. However, it is unclear to what extent individual species versus community interactions within the microbiome are linked to host fitness. Here, we combinatorially dissect the natural microbiome of

Indexed as

AnimalsBacteriaBiodiversityDrosophila melanogasterEpistasis, GeneticFertilityGastrointestinal MicrobiomeGastrointestinal TractGerm-Free LifeHost Microbial InteractionsLongevityMicrobial InteractionsMicrobiotaPhenotypeReproductionDrosophilafitness landscapehigher-order interactionslife history tradeoffsmicrobiome

Identifiers

PMID30510004
PMCPMC6304949

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.